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Risks rise as ISSCR drops strict 14-day rule on human embryo growth in the lab

May 27, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Something called the 14-day rule on growing human embryos in the lab helped keep a tough question in check for a long time: when is it ethically wrong or just practically unwise to continue growing a human embryo for research? There is no good answer based on science or anything else. ISSCR moves beyond strict

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Duke Autism Center has Panama clinic to thank for $10s millions?

October 13, 2020 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Drs.-Neil-Riordan-and-Joanne-Kurtzberg-MSCs-for-autism

What do a Panama stem cell clinic and the Duke Autism Center have in common? More than I might have imagined. It’s a remarkable story that needs telling. Duke Autism Center There is a puzzle when it comes to the controversial idea of using cord blood for autism. Why? Because two of the strongest proponents

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Prop 14 polling on CIRM re-funding stays moderately upbeat

October 5, 2020 / Professor Paul Knoepfler, Ph.D. / 8 Comments

The State of California is considering re-funding its stem cell agency, CIRM, to the tune of more than $5 billion dollars, but the issue has generated surprisingly little media attention. The main coverage has been by David Jensen over at California Stem Cell Report. Prop 14 polling data non-existent in public domain To my knowledge,

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CRISPR often damages human embryo chromosomes

July 1, 2020 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a

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Duke Autism Center trial: no benefit of cord blood for autism

May 20, 2020 / Professor Paul Knoepfler, Ph.D. / 12 Comments

A solid new, blinded placebo-controlled Phase II study from the Duke Autism Center clearly shows no benefit of cord blood for autism. Surprisingly, the team has said they are encouraged by the results. As a result, they apparently will continue this kind of work anyway despite their data. In contrast, I see the data as a

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Seeing isn’t always believing: a cautionary tale on GFP transfer when trying to restore vision

November 27, 2017 / Professor Paul Knoepfler, Ph.D. / 4 Comments

By Samantha Yammine When our TV stops working, it’s usually because one of the wires has come unplugged. We begrudgingly huff and puff over to the back of the TV, track down the loose culprit, plug it back in, and boom: back to Netflix. If you multiply all those wires in the back of your

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Hateful politics infiltrate human genome editing debate in France

June 27, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

By Elliot Hosman Summary. A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman”

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Perspectives: no human genetic modification moratorium from organizers of #GeneEditSummit

December 4, 2015 / Professor Paul Knoepfler, Ph.D. / 7 Comments

I just got back from a historic summit on human genetic modification in Washington, D.C. New genetic modification technology, termed CRISPR-Cas9, has both made genetic modification a relatively simple matter for scientists and human genetic modification much more likely in the near future. Heritable human genetic modification could prevent some rare genetic diseases so there

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NAS Meeting on Human Germline Modification Taking Shape

September 14, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

The US National Academy of Sciences (NAS) will hold a meeting on heritable human germline modification on December 1-3, 2015 in Washington, D.C. Invitations to the NAS meeting to individuals starting going out last week. The upcoming NAS meeting seeks to address these issues and discuss the possibility of a moratorium on clinical use of

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