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Review of New ACT Paper on hESC-derived MSCs

March 27, 2014 / Professor Paul Knoepfler, Ph.D. / 17 Comments

Advanced Cell Technology (ACT; $ACTC) has a new paper out on using human embryonic stem cells (hESC) to make MSCs with potentially powerful therapeutic potential. The paper, entitled Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties, was published in the journal Stem Cells and Development. What’s the scoop on this […]

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Do You Believe in STAP Cells: Week 6 Poll

March 16, 2014 / Professor Paul Knoepfler, Ph.D. / 3 Comments

STAP cells, also known as STAP stem cells, have generated a lot of discussion and debate. It seems there are strong opinions on all sides. What do you think? Please take our poll.

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Seismologist from Japan looks at the STAP cells mess

March 13, 2014 / Professor Paul Knoepfler, Ph.D. / 17 Comments

I’m a seismologist at the University of Tokyo, where I’ve been since 1984. I was the first tenured foreign faculty member in the history of our university. If you look at my publication list on the Researcher ID site you can see that my main research recent interests are modeling seismic wave propagation and analyzing

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STAP coverage ruffles some ‘elite’ stem cell feathers

March 11, 2014 / Professor Paul Knoepfler, Ph.D. / 21 Comments

Will a few of the “elite” of the research world be on the wrong side of history when it comes to STAP cells? It seems some don’t want people talking about just how bad the STAP situation might be. Bad news may travel fast as the expression goes, but the people who talk about it may

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Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming

March 6, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from

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Latest STAP stem cell whispers: glimmers of hope or mirages?

March 3, 2014 / Professor Paul Knoepfler, Ph.D. / 4 Comments

On the STAP cell front, I’ve heard several reports now that labs can sometimes see some kind of either Oct4-GFP reporter activity or pluripotency gene expression in acid treated cells, but the scientists do not seem particularly encouraged. One said that the cells gave a glimmer of interesting gene expression, but would not grow at

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Interview with Dr. Teru Wakayama on STAP stem cells

February 27, 2014 / Professor Paul Knoepfler, Ph.D. / 19 Comments

I asked Dr. Teruhiko Wakayama, who goes by Teru to those who know him, if he would be willing to do a Q&A on the STAP stem cell situation. Teru was senior author on the STAP stem cell Nature letter on chimerism, but was not a senior (note this is a correction from an earlier version of this

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STAP stem cell new allegations: situation turns darker

February 27, 2014 / Professor Paul Knoepfler, Ph.D. / 34 Comments

I don’t know about you, but this whole STAP stem cell thing has got me kind of bummed out. Last night I was thinking to perhaps stop blogging about it as the situation turns darker, but it seems like it wouldn’t do any good to ignore it. The ostrich with head in the sand approach

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What is the FDA’s appropriate role in regulating medical innovations such as stem cells?

February 24, 2014 / Professor Paul Knoepfler, Ph.D. / 4 Comments

We need medical innovations, but what is the appropriate way for agencies like the FDA to regulate the process and fight bogus interventions based solely on hype? Without innovation, medicine becomes stagnant and hope fades for patients who have any one of numerous conditions that are currently inadequately addressed by medicine. I can relate on

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