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Mitalipov briefly responds to Egli preprint, stands by human embryo CRISPR pub findings

August 31, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

There has been a wave of intense discussions both in the public domain such as on Twitter and behind the scenes over the new Egli, et al. preprint that challenges the main conclusions of the Ma, et al. Nature paper from Shoukhrat Mitalipov’s lab. Ma, et al. reported CRISPR gene editing of human embryos, arguing for …

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How risky are stem cell trials for Parkinson’s beginning in China?

June 1, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

New human clinical trials using derivatives of pluripotent stem cells in China for Parkinson’s Disease (PD) have raised expectations and some eyebrows. PD is a neurodegenerative condition, sometimes diagnosed or followed by PET scans such as the one at left, characterized by loss of dopaminergic neurons leading to severe and sometimes life-threatening symptoms. Pluripotent stem …

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Splashy SacBee Ad for Stem Cell Clinic Nervana Raises More Questions

April 9, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

This morning my local paper The Sacramento Bee ran a full-page, super splashy ad for the local stem cell clinic, Nervana. Remarkably the ad says, “As Seen in The Sacramento Bee”, referring to an article by reporter Claudia Buck that ran in the past in the SacBee Insight section that raised many concerns and questions about Nervana. I may have …

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Dr. Jeffrey Weiss, SCOTS trial, & Patient Claims of Blindness

April 3, 2017 March 17, 2023 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Two physicians are central to something called the SCOTS trial, Dr. Jeffrey Weiss and Steven Levy. Patients have claimed negative outcomes after participating in the trial. What’s going on here? SCOTS trial The recent NEJM paper reporting on the blinding of three patients in Florida may be just the beginning. More information has come out on negative …

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8 key arguments, take-homes on day 1 of FDA stem cell meeting

September 12, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Today was the first part of the FDA’s 2-day meeting on stem cell draft guidances. It was a great meeting I thought. A few consistent themes and notable things emerged as raised by participants.

Zika infects and zaps human brain stem cells

March 4, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

There has been much attention to the link between Zika and microcephaly. How does Zika cause microcephaly or does it even directly cause microcephaly. Has the latter been concretely proven? There are even more questions. A cool new Cell Stem Cell paper gives us some key insights. The manuscript from a team led by Guo-Li …

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US Stem Cell Clinic sues anonymous critics for libel, seeks IDs from websites

February 22, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Last month the stem cell community learned that a patient of the business US Stem Cell Inc./US Stem Cell Clinic, previously known as Bioheart, had filed suit in a Broward County Florida Court against the publicly traded company alleging various charges including damage to her eye. Now US Stem Cell has more recently filed suit in the …

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New Nature papers debunk STAP cells

September 23, 2015 January 12, 2024 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Today marks nearing the completion of a full circle for one of science’s biggest controversies: the STAP cell fiasco. Today STAP cells are completely refuted with the publication of two new papers in Nature and we know much more–with some notable gaps still–about what went wrong. STAP cells debunked In January of last year, an …

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

May 20, 2015 February 1, 2021 / By Chris Scott / 1 Comment

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way …

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News bites & rumors on human embryo genetic modification

April 30, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal …

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