January 17, 2021

The Niche

Trusted stem cell blog & resources

Search Results for: peer review

1 min read

Post-publication (post-pub) peer review is one of the hottest topics in science today. Post-pub review means review of the scientific literature after papers come out. Post-pub review can take place on websites dedicated to it such as F1000 or PubPeer as well as on various blogs and even via comments on PubMed. In our first poll, please indicate your view on post-pub review. Then if you generally have a positive view of it, please indicate the main reason in the 2nd poll. Or if you generally …Read More

5 min read

Do you feel frustrated with the current peer review system in science? I have an idea that might help and it involves the revolutionary idea of reviewer accountability. In other words, authors and grant writers in essence review their reviewers. I’ve made this all the easier for you with templates that you can simply and quickly fill in and then submit regarding a paper review to the journal editor or regarding a grant review to the funding agency. Ever wonder what the heck a …Read More

3 min read

I was critical earlier this week in a post of what I perceived to be the over-the-top reaction to the whole Higgs Boson situation and press fest. I went so far as to call it “hysteria” or one could say “Higgstery“. In turn, I was criticized for that blog post for being too critical and spoiling people’s excitement and fun. What a wet blanket I am, right? However, I stand by the post after giving it more thought. My concern here is not whether the scientists …Read More

4 min read

A year ago I did a post on scientific peer review and the dreaded Dr. No, but have things gotten any better? No. From everyone I have talked to, the answer would seem to be quite the contrary–things continue to move in the wrong direction. If you are not a scientist, but care about stem cell research, why should you care if peer review is flawed? Because the problems in peer review significantly slow down the field! A new article just came out on this …Read More

3 min read

Update: Now in 2020 it seems that peer review remains very problematic. The Scientist has a few pieces out on the trouble with peer review including my personal favorite: I Hate Your Paper. That article rings so true as do the quotes from the scientists. Peer review in the stem cell field and the IPS cell subfield in particular is even worse than average. It is not unusual for a reviewer to ask for something simply for the purpose of either killing or delaying a …Read More

3 min read

Post-publication (post-pub) review is arguably one of the most innovative developments in scientific publishing in the past few years, including at the site PubPeer. An illustration of the widespread influence of post-pub review is the fact that PubMed recently started allowing readers to post comments about any paper.  Post-pub review drove the rapid debunking of the now retracted STAP papers. Post-pub review, which comes in two main forms (anonymous and non-anonymous), is a powerful phenomenon manifesting on a number of websites and blogs including the …Read More

8 min read

Introduction to CAR-T cells CAR-T cells are an exciting cutting-edge technology that has been garnering great interest including in the stem cell field. Potential therapeutic uses of CAR-T, which stands for Chimeric Antigen Receptor T-Cells (CAR-T), are being studied in clinical trials as immunotherapies to potentially fight cancer as well as many other diseases by using one’s own immune system. The process of CAR-T therapy (see diagram below) starts off with the collection of the patient’s own T-cells through apheresis. The cells are then …Read More

3 min read

For the past few years post-publication peer review (PPPR) has grown in influence and one particular website, PubPeer, has become the primary go-to place specifically for blunt PPPR. The kind that happens in journal clubs in labs across the world. Comments on PubPeer have led to numerous serious corrections and retractions of flawed articles. I’m most familiar with its role in the STAP cell case. Both the founders of and most of the commenters on PubPeer have remained anonymous. That is until today. The founders …Read More

3 min read

A heated series of discussions on stem cell publications is ongoing on the Post-publication review (post-pub) website, PubPeer, which has been called by a PubPeer user “The stem cell shoot out“. This “shoot out” goes well beyond the one page on PubPeer. It is notable to see that the authors of the papers that are the focus of these interactions, often prominent stem cell scientists, are now sometimes participating in the discussions by leaving comments themselves on PubPeer. For instance, Austin smith has commented on PubPeer regarding ground …Read More

2 min read

I recently started a poll on this blog asking for people’s views of post-publication (post-pub) review. Post-pub review includes a wide range of formats of reviews of scientific publications that occurs, as the name suggests, happens after the paper in question is published. In contrast, of course, peer review of papers happens before publication. Post-pub review is becoming increasingly common today in science, but it is so new that there is a range of views on it. I wanted to sample people’s views of it …Read More