Five legends and a blogger walk into a bar together. The bartender asks the first legend “What can I get for you?” The legend orders their drink. The bartender eventually serves up drinks to all five legends and turns to the blogger, “And what can I get for you?” The blogger replies, “Do you have Wi-Fi? […]
A few days ago I had a long, very enjoyable phone conversation with the father of the mesenchymal stem cells (MSC) field, Dr. Arnold Caplan. Dr. Caplan is Professor of Biology, Director Skeletal Research Center at Case Western. He coined the phrase “mesenchymal stem cell” in the late 1980s. I’m going to break the interview
Insightful interview with Arnold Caplan: Part 1: MSC history, nomenclature, & properties Read More »
The so-called “SafeCell” paper from the journal PLoS One is one that a number of advocates of deregulation of the stem cell industry often have mentioned to me: Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials I have read this paper and have some thoughts on it. As
An interesting paper just came out in PNAS reporting the apparent presence of a pluripotent stem cell population in the adult breast. The paper is Roy, et al. and is from Thea Tlsty’s outstanding lab at UCSF. I have read the paper and it seems very solid technically to me. The finding has stimulated some
Caution on mammary pluripotent stem cell paper Read More »
Is this a “good” stem cell blog post to write as I gobble down my lunch in between working on grants….hmm, maybe not. Too late! Stem cells are hot all around the globe, but they are particularly scorching hot in certain countries such as the Philippines. There are an increasing number of news articles on
Please pass on bull testicles Soup No. 5 & on stem cell Soup No. 7 Read More »
Two women in San Diego County are heading to jail after being convicted and sentenced for fraud related to stem cell treatments.The women injected concoctions of bovine stem cells from Germany and DMSO into patients. You can read the details of the original arrest here on the FBI website. According to a Modesto Bee article, Kathleen
A concerning trend in the for-profit stem cell field, but one that does not get enough attention, is self-experimentation by those selling (often unlicensed) stem cell treatments. In other words, the stem cell clinic leaders and docs often not only sell stem cell treatments to patients, but also they give themselves the same treatments, often repeatedly.
The dangers of stem cell self-experimentation: cartoon & discussion Read More »
The mesenchymal stem cell (MSC). So important and yet so misunderstood? People pronounce it in different ways. People isolate the MSCs in different ways. Each person’s MSCs are very different. Each lab’s MSCs are different. (see picture above of MSCs showing fibroblastic morphology; source is Wikipedia) Someone once told me that MSCs are the same
Would an MSC by any other name still smell as sweet? Read More »
Recently I spoke about cancer stem cells at a retreat. The presentation style was informal and enjoyable as it allowed for people to talk frankly about topics. It encouraged questions and outside-the-box thinking. As I was eating some yogurt at breakfast at the meeting awaiting my turn to speak, I decided I would scrawl my
My ‘back of napkin” list of top action items for cancer stem cell field Read More »
The Korean-based stem cell biotech, RNL Bio, which also does business in the U.S. as RNL Bio and Human Biostar Inc, reportedly (seems to be a press release, PR) has filed an investigational new drug (IND) application with the Korean FDA (KFDA). The purpose of the application is to test the efficacy of autologous adult stem cells