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Clinicaltrials.gov Mission At Risk From Proliferating For-Profit Trials

October 14, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

It’s hard to even imagine the world of investigative medicine without the wonderful resource of Clinicaltrials.gov, the global hub for clinical trial listings. I recently interviewed the Director of Clinicaltrials.gov, Dr. Deborah Zarin here, which is a fascinating read. As great as Clinicaltrials.gov is as a resource, unfortunately it faces a new, rapidly growing problem that is a serious …

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Home stretch on October deadline NIH grant & I’m…(fill in the blank)

October 1, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Grant deadlines are no picnic. Like thousands of scientists around the US, I too am working on a big NIH grant proposal due in a matter of a few days. If you are also in this boat, how are you all feeling right now since it is October 1st? How would you complete this sentence: “I need to …

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Interview with Clinicaltrials.gov Director Deborah Zarin

September 24, 2014 March 6, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

This post is the first in a series about the Clinicaltrials.gov website. This piece is an interview the Director, Dr. Deborah Zarin. I want to thank her for taking the time to answer my questions. Later, I will post Part 2 in which I discuss my concerns about the trend of for-profit stem cell clinic trials …

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What do sperm have to do with brain tumors?

September 21, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3 binds to the actual …

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NIH Finds Old Small Pox, Ricin: What’s in Your Lab?

September 16, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

There can be weird old stuff in the freezers, fridges, and elsewhere in labs. Most labs try to do the equivalent of a spring cleaning now and then to make a dent in the accumulation of this kind of stuff. Recently the NIH found various old stuff in their labs including two very unnerving findings: living smallpox and …

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ACT reinventing itself with new name Ocata Therapeutics

September 12, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Here is a link to the Ocata website, marking the start of a new era for what was formerly Advanced Cell Technology or ACT. It’s been a big summer for stem cell biotech Advanced Cell Technology (ACT; stock ACTCD) as it continues what I would call a process of reinventing itself. What’s been happening? ACT recently …

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STAP papers blistered by Nature’s own reviewers were then accepted

September 11, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 27 Comments

The reviews of a STAP paper submitted to and rejected by the journal Science in 2012 were posted at Retraction Watch yesterday. They filled in some gaps in the puzzle of the series of events that led to such flawed science being published in Nature in January 2014, but the reviews also raised more questions. Today, more STAP paper …

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Full Reviews of Rejected STAP Paper Point to Early Signs of Big Trouble

September 10, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Before the two STAP cell papers were published in Nature in January of 2014, much of the same data was reportedly submitted as single papers to other high-profile journals including Science. In these cases, the proto-STAP papers as we might call them were rejected. But why? Until now we largely could only speculate. However, the reviews …

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Interview with Neuralstem CEO Richard Garr

September 8, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

I invited Neuralstem CEO, Richard Garr, to do a Q&A interview and he kindly accepted. The interview provides some novel insights into this major biotech in the stem cell sector. 1. How is Neuralstem doing today? What programs are underway that you find particularly exciting? Garr: Neuralstem is moving on all cylinders these days on …

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In polling, most scientists would go to grad school again & here’s why or why not

September 5, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I am doing some polling on whether people who have finished graduate school would go again, why or why not, and what their current position is at this time. I found the responses to be surprising and interesting. Almost two-thirds of respondents indicated they would do grad school again if given a do-over. Despite all the …

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