Search Results for: Genetics

TGIF: Biomedical weekend reading includes some cool papers

TGIF: I’m working on an R01, but I still try to find time to read a wide variety of papers. Below are the science pubs that I’m hoping to get to this weekend. Less Myc, longer “health span” Cell paper from Sedivy Lab. ESC Histone H3.3 nucleosomal functions Epigenetics & Chromatin paper from Keji Zhao Lab. Human […]

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Horwitz Interview Zooms in on Allen Cell Institute: the GoogleMaps of Cells

Rick-Horwitz

One of the most exciting developments in the biomedical sciences in 2014 was the announcement of the new Allen Institute for Cell Science. This new institute, which will be focused on cell biology, received $100 million in funding from high-tech pioneer and philanthropist, Paul Allen. I am very curious about how the institute will tackle cell

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Review of Bert Vogelstein “Bad Luck” Cancer Science pub

cancer-stem-cells

A new paper in Science by Bert Vogelstein suggests that a good part of cancer is attributable to bad luck. There are so many big questions about cancer. They resonate with me very strongly as a cancer researcher and a cancer survivor myself (more on my cancer story here). What really causes cancer? Why does

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About Us, The Niche and Knoepfler Lab

Knoepfler-Lab-2019

The Niche is the top, most authoritative stem cell and regenerative medicine blog on the web. It’s the only one to our knowledge written mostly by a professor. Professor Paul Knoepfler of UC Davis School of Medicine, an internationally respected stem cell biologist and educator, runs The Niche. Knoepfler is an advocate of rigorous evidence-based

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Will Lawsuit Against PubPeer Chill Post-Pub Review?

PubPeer

Post-publication (post-pub) review is arguably one of the most innovative developments in scientific publishing in the past few years, including at the site PubPeer. An illustration of the widespread influence of post-pub review is the fact that PubMed recently started allowing readers to post comments about any paper.  Post-pub review drove the rapid debunking of the

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Response from Drs. Braude & Lovell-Badge to My Letter on Mitochondrial Transfer, 3-Parent Technology

3-parent-baby

The following is a response to my Open Letter to the UK Parliament on mitochondrial transfer/3-parent technology from Drs. Peter Braude and Robin Lovell-Badge. Dear Professor Knoepfler, We read your open letter to the UK Parliament and the Science and Technology Committee with interest and concern. We are two scientists, like you, with particular interests

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What is the connection between sperm and brain tumors?

H3.3

Sperm and brain tumors? Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3

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Could Nature’s 2-year torrent of paper retractions be a good thing?

Nature

The last two years at Nature Magazine have seen a surprising wave of paper retractions. In 2013 and now just so far in 2014, Nature has retracted a total of 14 papers. How unusual is that? Historically, Nature retracts relatively few papers, perhaps just under two per year on average. What the heck has been going on in 2013-2014? Let’s break it

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