The international stem cell policy and ethics think tank, the Hinxton Group, weighed in yesterday on heritable human genetic modification with a new policy statement. The Hinxton statement is in many ways in agreement with the Baltimore, et al. Nature paper proposing a “prudent path forward” for human germline genetic modification, which came out of […]
Perspectives on Hinxton Human Germline Modification Statement Read More »
For the past few years post-publication peer review (PPPR) has grown in influence and one particular website, PubPeer, has become the primary go-to place specifically for blunt PPPR. The kind that happens in journal clubs in labs across the world. Comments on PubPeer have led to numerous serious corrections and retractions of flawed articles. I’m most
PubPeer founder neuroscientist Brandon Stell Read More »
There has been a great deal of excitement during the past several years over the regenerative medicine work of often-called “super surgeon” Dr. Paolo Macchiarini. For an update on Paolo Macchiarini from a recent scathing Vanity Fair piece, see here. Hei has done pioneering work. For instance, he created and transplanted bioengineered windpipes that were produced in
Paolo Macchiarini cleared of misconduct, but some charges remain Read More »
The Japanese public broadcasting system, NHK, has been accused by scientist Haruko Obokata of violating her human rights. Obokata was the primary researcher involved in the STAP cell fiasco in which two ultimately retracted Nature papers contained duplicated, plagiarized, and manipulated data. She was certainly not the only researcher on those papers, but overall she
Did NHK Violate Rights of Obokata (小保方 晴子) on STAP? Read More »
Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part
Kelly Hills interview: human genetic modification & bioethics Read More »
In a poll on CRISPR, respondents so far have predominantly viewed potential off-target effects as a moderate (28%) to substantial (25%) problem. The poll is still running if you are interested in participating. As to the more polar answers, only 20% and 4% answered “minor” or “a non-issue”, respectively, while 14% thought that off-target effects
CRISPR off-target effects important, but not severe challenge, says poll Read More »
Gene drive is a powerful, emerging genetic technology that can force genetic modification into an entire population. For more background on gene drive you can read my previous post. It’s a very exciting, but potentially dangerous technology with sizable possible risks. Recently I had an intriguing conversation with leading geneticist Harmit Malik on gene drive. What
Conversation with Harmit Malik on Gene Drive & Genetics Read More »
TGIF recommended weekend reads including thought-provoking reading over a beer, glass of wine, or beaker…and what would RNA taste like? Two from Alexey Bersenev The future of human limb bioengineering Translating Cell Therapies: Academic versus Industry model CIRM blog: two cool recent posts Specialized Embryonic Stem Cells Yield Insights into X Chromosome Inactivation Da Mayor and
TGIF: recommended weekend science reads & a jar full of RNA Read More »
Earlier this week I posted an interview with Steven Pinker on CRISPR, human germline modification, and bioethics. With only a few exceptions, I strongly disagree with Pinker’s philosophy in these areas and I knew going into the interview that his answers would likely go against my own views. I also expected the interview would anger
Why interview Steven Pinker on my blog if I strongly disagree with him? Read More »
Scientists studying genetics are both excited and worried about a powerful, new technology called “gene drive“. Some have been raising serious concerns about gene drive and in certain cases calling for proactive regulation, which is unusual in science. This method is so powerful because it is designed to induce genetic changes in an entire population
Exciting CRISPR-powered “gene drive” also has scientists deeply concerned Read More »