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250,000-fold oversight on 3-person IVF mitochondrial transfer?

June 23, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Remember the debate over so-called 3-person IVF? The goal of this technology, also referred to as mitochondrial transfer and 3-parent IVF, is to prevent mitochondrial disease through nuclear transfer in oocytes or one-cell embryos. The resulting genetically modified (GM) human embryos and ultimately children if it works could have dodged mitochondrial disease, but also could have serious or […]

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Public polling on human gene editing, moratorium

May 21, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Many of us scientists, ethicists, and legal scholars are working on educational outreach to the public on the potential use of gene editing technologies like CRISPR to genetically modify human beings, but clearly there’s a long way to go and much more to do on this front. By the way, you may find this new

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News bites & rumors on human embryo genetic modification

April 30, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal

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Hank Greely Human Germline Modification Post

April 10, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Hank Greely over at The Center for Law and Biosciences at Stanford Law School was one of the participants in the recent Napa meeting on approaches to human germline genetic modification. Hank was also one of the authors on the resulting position paper in Science with David Baltimore as first author (here). Now Hank, pictured below,

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Is ‘genetically modified human’ a loaded name?

April 5, 2015 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Should we be using the term ‘genetically modified human’ in discussions of heritable use of CRISPR in people? During the still ongoing discussions of genetic modification in the human germline and potentially in actual human beings in the future, an interesting, but difficult question has emerged: What words or names would be most appropriate for

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What Would Spock Say About Grouchy ‘Practical Ethics’ Piece on Human Genetic Modification?

April 2, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Over at Practical Ethics they are calling for an almost Spock-like, emotion-free, and logical approach to the topic of heritable human genetic modification. Sounds good in principle, right? Well, unfortunately it fails in execution in their essay. The authors of “Editing the germline – a time for reason, not emotion” seem to include Chris Gyngell, Tom

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David Baltimore, et al. path for human germline engineering

March 19, 2015 / Professor Paul Knoepfler, Ph.D.

In a new perspectives piece in Science, Nobel Laureate David Baltimore and co-authors including Jennifer Doudna and George Church, chart a potential path forward for human germline engineering. See also accompanying Bioethics piece by Gretchen Vogel as well, “Embryo engineering alarm”. In the piece, entitled “A prudent path forward for genomic engineering and germline gene

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About Us, The Niche and Knoepfler Lab

December 4, 2014 / Professor Paul Knoepfler, Ph.D. / 10 Comments

The Niche is the top, most authoritative stem cell and regenerative medicine blog on the web. It’s the only one to our knowledge written mostly by a professor. Professor Paul Knoepfler of UC Davis School of Medicine, an internationally respected stem cell biologist and educator, runs The Niche. Knoepfler is an advocate of rigorous evidence-based

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