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Congress: FDA should consult religious experts on embryo CRISPR

June 28, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Crystal_Structure_of_Cas9_in_Complex_with_Guide_RNA_and_Target_DNA

The US Congress recently held its first hearing on human germline genetic modification. The meeting included CRISPR-Cas9 pioneer Jennifer Doudna (see video here) on the panel. See image of Cas9 structure from Wikipedia. CRISPR-Cas9 is a powerful, strikingly efficient tool for genetic engineering of cells and whole organisms. Now Republican congressional leaders have included a […]

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Doudna & Others Testify to Congress on CRISPR, Human Germline Editing

June 19, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The House Subcommittee on Research and Technology on Tuesday held a CRISPR hearing: “The Science and Ethics of Genetically Engineered Human DNA”. At the meeting, CRISPR pioneer Dr. Jennifer Doudna gave testimony along with Dr. Victor Dzau who is the President of the Institute of Medicine (IOM) of the National Academy of Sciences (NAS), Dr.

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White House supports moratorium on heritable human CRISPR

May 27, 2015 / Professor Paul Knoepfler, Ph.D.

The Obama Administration today weighed in on human germline genetic modification such as via CRISPR via a note from John Holdren, Assistant to the President for Science and Technology, and Director of the White House Office of Science and Technology Policy. The White House indicated support for the National Academy of Sciences (NAS) and the National Academy

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CRISPR critters: Cute pics of Cas9 gene edited animals

May 24, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

May 20, 2015 / Chris Scott / 1 Comment

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way

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Doudna most deserving of CRISPR Cas9 patent, says poll

May 3, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

With more than 250 votes cast, Jennifer Doudna is leading by a decisive margin in a poll asking who deserves the patent for use of CRISPR-Cas9 as a tool. Feng Zhang got only just over half the votes of Doudna. Another take home message from this poll is that a sizable minority–almost one in five– said

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The big blind spot on CRISPR for human embryo editing: PGD

April 24, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the

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Who deserves patent for CRISPR-Cas9 in human cells? Take our poll

April 21, 2015 / Professor Paul Knoepfler, Ph.D. / 6 Comments

There is no hotter technology than CRISPR-Cas9 gene editing tools. Perhaps it is not surprising then that there is a patent dispute over it, which falls into two camps: (1) Jennifer Doudna & Emmanuelle Charpentier, and (2) Feng Zhang. Who deserves the intellectual property for use of CRISPR-Cas9 in human cells? Take our poll.

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Jennifer Doudna Interview on CRISPR, Human Gene Editing

April 14, 2015 / Professor Paul Knoepfler, Ph.D.

I’m doing a series of interviews with leaders in the field on human germline modification with the first interview in this series with George Church and today’s second in this series is a conversation I had with Dr. Jennifer Doudna, a pioneer in CRISPR-Cas9 technology. Doudna is a Professor in MCB and Chemistry as well

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5 new cool papers on CRISPR Cas9 gene editing

April 8, 2015 / Professor Paul Knoepfler, Ph.D.

CRISPR Cas9 is a relatively new, powerful approach to gene editing and genetic modification more generally. In the relatively short window of time in which this technology has been widely available for gene editing applications it has already evolved rapidly to become more powerful. Here are some new papers of interest on this technology. With

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