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Nita Farahany Interview on Human Germline Modification: Defining A Road Forward

July 28, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

The topic of heritable human genetic modification has been heating up recently. Prominent scientists, ethicists, and legal scholars have being weighing in, and there is a range of attitudes. Some favor a complete, moratorium including even lab work, while on the other end of the spectrum there are those who have a more liberal perspective. Many …

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Super stem cells meetings, & courses remaining in 2015

July 5, 2015 March 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

There are a whole bunch of wonderful stem cell meetings, conferences, and courses remaining in the second half of 2015. If you are organizing (or just know of) another one and don’t see it listed here please let me know and I’ll add it in. I’m starting to collect those for 2016 as well so …

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How much human genetic variability is there really?

June 1, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

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At a genetic level, just how much do each of us human beings vary from each other in our total genome sequence? The number I was taught in Genetics at some point was that the genomes of any two human beings are likely to be 99.9% identical. So only about 1 out of 1,000 bp …

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CRISPR critters: Cute pics of Cas9 gene edited animals

May 24, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM …

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DIY human ‘upgrades’ via biohacking

May 22, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Heritable human genetic modification has been the topic of the year so far, but another trend is edgy and interesting: non-heritable, but cutting edge forms of human modification that in some ways fall into the class of biohacking. Biohackers are into do-it-yourself (DIY) forms of biology including self-modification. Sure, people have been modifying themselves for …

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

May 20, 2015 February 1, 2021 / By Chris Scott / 1 Comment

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way …

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Stanford Human Germline Modification Meeting: Medicine, Science, Ethics, & Law

May 18, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of …

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GMO: Why 3 Such Difficult Little Letters?

May 5, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

What is a GMO? I realized a few years ago that I really should know a lot more about the whole debate over genetically modified (GM) organisms (GMOs). What are the facts on GMOs? As a scientist who has for many years done amongst other things genetics research including making and studying so-called “knockout mice” …

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George Church on Germline Human Genetic Modification

March 9, 2015 January 21, 2023 / By Professor Paul Knoepfler, Ph.D. / 17 Comments

I recently interviewed leading genomics scientist George Church on the ways that trends in genomics are changing our world. We also discussed the possibility of heritable human genetic modification. These days we more often call this “CRISPR babies.” His answers suggest that genomics and gene editing are poised to radically change our world. They could literally …

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Are babies from same-sex couples possible?

March 3, 2015 March 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

A question that has come up with advances in stem cell technology: could same-sex couples have their own biological children? Since Shinya Yamanaka reprogrammed first mouse and then human ordinary cells into powerful pluripotent stem cells, termed induced pluripotent stem (iPS) cells, back in 2006-2007 many new research avenues have opened up. The impossible suddenly …

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