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Key Mayo Clinic stem cell webpage is overexuberant & outdated

March 21, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Mayo Clinic does some great research on stem cells and regenerative medicine. However, at times I’ve felt that a few Mayo researchers are overexuberant. This mainly relates to certain not-yet-proven stem cell and related offerings. Fitting with that perception, the Mayo website also has some inaccurate stem cell content that leans toward overstating things. […]

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Weekly reads: elephant stem cells, RIP Connie Eaves, AI cell biology

March 17, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Last week one of the most popular stories was about a preprint from a mammoth de-extinction research group led by George Church having made elephant stem cells. I finally got a chance to look carefully at their preprint. Elephant stem cells preprint and mammoth de-extinction The elephant stem cells preprint has solid data. It looks like

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Weekly reads: gene therapy nod, Nature pub ethics, CRISPR LDL

May 21, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Totipotency literally means all powerful, but it refers in biology to specific cells. These cells can make every type of cell in the body of an organism plus the extraembryonic tissues needed for development. This includes humans. So if you could reprogram human cells like blood or skin cells into totipotent stem cells, you might

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Pros & cons of dead celebrity genomics

March 28, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Are there any guidelines for genomics studies of famous dead people like sequencing their genomes? It doesn’t seem like it. I remember when I first heard of the idea of trying to clone John Lennon from an old molar. Fortunately, as far as I know no one ever tried that, but it wouldn’t surprise me if

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Are immortal jellyfish actually mortal?

January 24, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

About ten years ago I ran across the organism called the immortal jellyfish. Luckily I didn’t get stung because it wasn’t an in-person encounter like while swimming. Rather, I came upon the idea that these guys lived forever. Someone was even selling an immortal jellyfish extract. They claimed it would reverse aging in people. That

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2nd chances after big misconduct? He Jiankui, James Wilson, others

December 8, 2022 / Professor Paul Knoepfler, Ph.D. / 3 Comments

There have been rare instances like with scientist James Wilson where researchers were involved in what I would call major misconduct but somehow managed to bounce back. In a sense, they were given second chances in part by regulators but also by other scientists or supporters. However, after extraordinary misconduct, especially contributing to the death

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Obi-Wan Kenobi series review: lots to like but many plot holes

July 7, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Obi-Wan Kenobi Darth Vader light saber battle

I’m a Star Wars fan so I go into watching new Star Wars shows like the Obi-Wan Kenobi series already wanting to like them. It’s kind of akin to being a grant reviewer and being assigned a grant to review whose focus is already a passion of yours. However, after what I would call an

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Weekly reads: news, legos for stem cells, FDA, cancer, more

September 19, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

I’ve been busy recently focusing more on grant and paper writing than reading papers on stem cells, but my piece on trying to de-extinct mammoths via cloning-like methods drew strong opinions on both sides. Recent news and resources on stem cells We’re still awaiting a verdict in the big California federal court case where the FDA is

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What are embryonic stem cells & where do they come from?

March 8, 2021 / Professor Paul Knoepfler, Ph.D. / 3 Comments

What are embryonic stem cells and how do we scientists obtain them? My lab here at UC Davis School of Medicine has been doing research on embryonic stem cells for more than 14 years. You’ve come to the right place for expert answers on these very intriguing cells. What’s in this article Where do embryonic

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Will Stem Cells Save the Northern White Rhino?

March 3, 2021 / Ricki Lewis / 3 Comments

The title of a new article in Stem Cells and Development may seem audacious to those unfamiliar with the plight of the northern white rhino and the promise of induced pluripotent stem cells. But “Rewinding Extinction in the Northern White Rhinoceros” may turn out to be accurate for what a genetically diverse stem cell bank

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