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Arthur Caplan Article on Bogus Stem Cell Research: Some Different Views

May 22, 2014 / Professor Paul Knoepfler, Ph.D. / 2 Comments

When bioethicist Arthur Caplan talks about stem cells, people pay close attention and for good reason. Caplan has provided important perspectives on the stem cell field over the years. For example, you can see a guest post on this blog here about human cloning. However, in my post today I respectfully discuss how I disagree with several parts of this week’s piece by […]

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TGIF! Some attempts at humor to release STAP cell stress

May 9, 2014 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Sometimes a situation is so bad or stressful that it just calls out for some comic relief and the STAP cell mess seems to be one of those. Below are various silly attempts at STAP humor to hopefully release some of that stress. (By the way you might enjoy this 2020 piece on whatever happened to

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Perspectives on Lee Lab F1000 Paper that STAP Cell Method Does Not Work

May 8, 2014 / Professor Paul Knoepfler, Ph.D.

A paper has been published reporting that repeated attempts to make so-called “acid bath stem cells” have failed. At the end of January it was claimed in two Nature papers that a mild acid treatment created pluripotent or even totipotent stem cells that that the authors termed “STAP cells” or “STAP stem cells” (collectively referred

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Google Shows Us Crazy STAP Cell Dichotomy

April 17, 2014 / Professor Paul Knoepfler, Ph.D. / 16 Comments

Sometimes when we Google things we can find out surprising things about specific topics including the whole STAP cell train wreck. When I recently searched for STAP, here was my reaction: What the heck? A recent Google search for STAP cells yielded these two adjacent, completely contradictory results sourced from two Obokata mentors (see image

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After nightmare stem cell week, some good news?

April 13, 2014 / Professor Paul Knoepfler, Ph.D. / 7 Comments

We in the stem cell field should call this past week: A Nightmare on Stem Street. I can’t think of many weeks that have been worse for the stem cell field than this past one. I’m a new week is starting soon. It was a real nightmare, although I wish it was just something fictional

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STAP April Update: Super Stressful on All Fronts

April 7, 2014 / Professor Paul Knoepfler, Ph.D. / 14 Comments

What’s going on with the STAP cell situation now that it is into its third month? It’s getting worse instead of better or clearer, at least in part due to RIKEN’s incomplete investigation. What’s going on with STAP? New RIKEN Press Conference RIKEN reportedly held an odd sort of limited press conference today that TJO

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STAP Cell Nature Papers: Cases For & Against Retraction

March 31, 2014 / Professor Paul Knoepfler, Ph.D. / 11 Comments

What next for STAP? Is retraction of the two papers on the near horizon? It has been two months now since Nature published the two papers on STAP cells and STAP stem cells. There has been a storm of controversy surrounding these papers and the claims they made to easily produce the most powerful of

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Clues as to the real STAP cell scoop: a trio of biosci traps

March 25, 2014 / Professor Paul Knoepfler, Ph.D. / 16 Comments

I don’t really hear from almost anyone who fully believes in the STAP cell thing anymore. The most common thing I do hear is from people assuming STAP is largely or entirely wrong and asking, “what really happened?” There’s still a chance that STAP is real, but if I were in Vegas or at the

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Nature Rejects Paper Reporting that STAP Does Not Work

March 24, 2014 / Professor Paul Knoepfler, Ph.D. / 19 Comments

Dr. Ken Lee’s lab has done some very important validation attempts on STAP cells and has posted them on ResearchGate. To my knowledge, his lab’s STAP experiments are the ones in the public domain that most closely matched the methods of the Nature STAP papers. Dr. Lee submitted the work to Nature Brief Communications Arising

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Reactions to New On-Line Vacanti Lab STAP Cell Protocol

March 20, 2014 / Professor Paul Knoepfler, Ph.D. / 26 Comments

The Vacanti Lab at Brigham and Women’s Hospital/Harvard Medical School has now posted online their own version of the STAP cell production protocol. The thing that first struck me most strongly about this published protocol is that it is not the same protocol reported in the Nature papers and it also is not the same

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