This is a guest post on Cancer stem cells By Aaron Goldman Much like the winter weather we’ve been enduring on the east coast, cancer research is advancing at a rapid clip! For decades, researchers have considered pools of “cancer stem cells” (CSC) as the subsets within a tumor which both initiate progression and underpin […]
The FDA mandate to regulate drugs and devices often invokes a term called “interstate commerce”. Like many people I thought I knew what that meant, but probably like most people I was wrong. After a great discussion on an original post on various key issues related to the many stem cell clinics doing non-FDA approved
The Niche is the top, most authoritative stem cell and regenerative medicine blog on the web and the only one to our knowledge written by a professor. It is mainly written by Professor Paul Knoepfler of UC Davis School of Medicine, an internationally respected stem cell biologist and educator. Knoepfler is an advocate of rigorous
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Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill
Are glioma stem cells a path to better outcomes? Read More »
The STAP papers on making iPS like cells using acid treatment of differentiated cells really has people talking. See embryo at right made from GFP reporter STAP cells that glow green. As I said in my review of the papers yesterday, there are still some critical things we do not know about STAP cells and I
More thoughts from STAP acid reprogramming stem cell paper Read More »
In two Nature papers (here and here) published today researchers report the astounding finding of reprogramming differentiated cells back to a pluripotent or even totipotent state simply by exposing the cells to extreme environmental stress, creating cells they called STAP cells. Update: see more thoughts on STAP stem cells here. STAP cells: stressing the cell
Review of Obokata STAP cells Nature papers Read More »
The Knoepfler Lab conducts stem and cancer cell as well as chromatin/epigenetics research at the UC Davis School of Medicine. Our team has two big picture goals: (1) catalyzing the development of more effective treatments for cancers based on targeting stem cell-related machinery in tumorigenesis and (2) producing safer stem cell-based regenerative medicine therapies. We are particularly
Need a new liver, pancreas, or other vital organ, then I’ll 3D print one right up for you…that is in about 10 years. My intern Lakshmi did a great job on her guest piece last week on the promise of 3D printing in stem cell-based bioengineering including organ and tissue production. It’s an incredibly exciting area of
Want to 3D Print Yourself a New Organ? Key Challenges Read More »
What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not
Stem cell journal club: dishing on Nature paper on making iPS cells inside mice Read More »
What is the deal with the crazy hullaballoo over the so-called stem cell test tube burger? On the surface, this pseudo-burger sounds kinda cool in a geeky, comic book kind of way, but when I dug just a little deeper, it turns out I’m left asking: where’s the beef? After the burger was mentioned briefly on
Where’s the Beef? Reality Check on Test Tube Burger Baloney Read More »