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Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

July 31, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve …

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Hateful politics infiltrate human genome editing debate in France

June 27, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

By Elliot Hosman Summary. A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman” …

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Will new gene editing tech NgAgo challenge CRISPR?

May 15, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 17 Comments

2020 Update: early NgAgo reports have been mostly discredited and there is doubt on its function as a gene-editing method. What could be better than CRISPR for gene editing? A new genetic modification technology called NgAgo has some researchers really excited. How does it compare to CRISPR? I’ll admit it that as a scientist who works on …

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George Church chat: CRISPR people, Zika, weapons

April 18, 2016 January 21, 2023 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George …

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ViaCyte on the Rise: First Diabetes Trial Data & Acquires BetaLogics IP

February 4, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

VC-01-post-implant-final1-e1503703572933, viacyte

Clinical research on Type I Diabetes is one of the most exciting and promising areas of stem cells and regenerative medicine for human disease. Two of the coolest companies out there in this arena have been ViaCyte and BetaLogics (owned by J&J). For more on ViaCyte see my interview with President and CEO Paul Laikind …

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Patent expert weighs in on CRISPR dispute between UC & Broad

January 19, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 19 Comments

The patent dispute on CRISPR between UC/Jennifer Doudna and The Broad/Feng Zhang has been the subject of major attention including in a recent piece on Stanford Center for Law & Biosciences Blog. There is a lot of confusion over this important CRISPR dispute so I turned to a patent expert for their take on this via an interview …

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CRISPR predictions for New Year of 2016

December 27, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

CRISPR is the hottest new biotechnology and the top development of 2015 according to Science Magazine. What will the new year of 2016 bring on the CRISPR front? It’s clear there will be more meetings on CRISPR ethics and policy (heck, we are having one right here at UC Davis on May 26), but what …

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GMO Sapiens book teaser: time to talk frankly on human genetic modification

October 23, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I’ve written a new book on human genetic modification. This is my second book as the first one was Stem Cells: An Insider’s Guide, which is currently the top stem cell book on Amazon. The new book is called GMO Sapiens: The Life-Changing Science of Designer Babies. You can pre-order it here at Amazon or over here at my publisher’s …

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Why interview Steven Pinker on my blog if I strongly disagree with him?

August 13, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Earlier this week I posted an interview with Steven Pinker on CRISPR, human germline modification, and bioethics. With only a few exceptions, I strongly disagree with Pinker’s philosophy in these areas and I knew going into the interview that his answers would likely go against my own views. I also expected the interview would anger …

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Steven Pinker interview: case against bioethocrats & CRISPR germline ban

August 10, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 15 Comments

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing …

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