It was just over a decade ago that I started making websites and it’s been a wild ride. My first site was at the domain name www.chromatin.com, which I was fortunate to have been able to get for a good deal way back when…I think in 2005. You can see here an early 2007 copy […]
~10th anniversary of my 1st website: reflecting on wild ride Read More »
A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes
Perspectives on pig human chimera paper Read More »
A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style
Quick journal club on IPSC anti-aging paper: cool, but outstanding questions Read More »
One of the hottest topics in the world of stem cells this year has been the REGROW ACT and at a larger level the movement for changes in FDA oversight of investigational regenerative medicine therapies (see my past posts on it here), so the related provisions in the 21st Century Cures Act are stirring much
Chat with Michael Werner of ARM on Cures Act regenerative medicine provisions Read More »
Editor’s note: this is a guest post from Dr. Semenow on her new educational DNA game that also invokes stem cells. She has the remarkable distinction of having been the first woman who was a science Ph.D. student at Caltech. Stay tuned for my coming interview with her on her experiences in science. Her Kickstarter campaign
DNA Ahead Game & More Struts Its Stuff Read More »
In the past year there has been a great deal of attention given to the potential use of CRISPR-Cas9 for gene editing in human embryos. An important recent development, described in a new NPR article by Rob Stein, is the use of CRISPR-Cas9 in healthy human embryos for developmental biology research by assistant professor Fredrik
Interview with Fredrik Lanner who is CRISPR’ing healthy human embryos Read More »
A stem cell/regenerative clinic firm called the Lung Institute is facing a filing of a proposed class action suit. Update: Note that this firm also goes by the name the Lung Health Institute and now as of 2019-2020 it does not appear to offer stem cells anymore, perhaps focusing on PRP. You might also find
Class Action Lawsuit Filed Against Clinic Lung Institute Read More »
After six and a half years blogging here, I’ve seen so much weird stuff. Not all of it was even “bloggable” due to its crazy, not-safe-for-work nature. For TGIF this week, here are 10 of the weirdest posts from this blog over the years. Where’s the Beef? Reality Check on Stem Cell Test Tube Burger
Some weird posts: testicle soup, Kim Kardashian, zombies Read More »
By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve
Gaetan Burgio New Data & Theory on NgAgo versus CRISPR Read More »
Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells
Yamanaka’s baby turns 10: ten IPS cell hot button bullet points Read More »