Search Results for: stem cells for ms

What is the connection between sperm and brain tumors?

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H3.3

Sperm and brain tumors? Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3 […]

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Landmark: patient receives first ever iPS cell based transplant

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Masayo-Takahashi-150x150

In a major first for the stem cell and regenerative medicine fields, a patient in Japan today received a pioneering transplant of a retinal pigmented epithelial (RPE) sheet made from induced pluripotent stem (iPS) cells, also known by the acronym IPSC. This is the first ever iPS cell-based transplant into a human. The patient is

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STAP papers blistered by Nature’s own reviewers were then accepted

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STAP-magic

The reviews of a STAP paper submitted to and rejected by the journal Science in 2012 were posted at Retraction Watch yesterday. They filled in some gaps in the puzzle of the series of events that led to such flawed science being published in Nature in January 2014, but the reviews also raised more questions. Today, more STAP paper

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Full Reviews of Rejected STAP Paper Point to Early Signs of Big Trouble

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Before the two STAP cell papers were published in Nature in January of 2014, much of the same data was reportedly submitted as single papers to other high-profile journals including Science. In these cases, the proto-STAP papers as we might call them were rejected. But why? Until now we largely could only speculate. However, the reviews

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Could Nature’s 2-year torrent of paper retractions be a good thing?

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Nature

The last two years at Nature Magazine have seen a surprising wave of paper retractions. In 2013 and now just so far in 2014, Nature has retracted a total of 14 papers. How unusual is that? Historically, Nature retracts relatively few papers, perhaps just under two per year on average. What the heck has been going on in 2013-2014? Let’s break it

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RIKEN fails to reproduce STAP, big CDB shake up expected

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STAP-stem-cells

Nikkei is reporting that the RIKEN internal attempt to replicate so-called STAP (acid bath) cells has failed. Update: apparently, although RIKEN calls the efforts preliminary, the team tried to make STAP an amazing 22 times and 22 times it failed. The rumors for weeks in the stem cell gapevine that RIKEN itself could not get

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Challenge tries to cancel Yamanaka iPS cell patent

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Patent-challenge

A new patent dispute has exploded in the stem cell field related to induced pluripotent stem (iPS) cells. What’s going on? In 2006, Shinya Yamanaka reported cellular reprogramming to create mouse induced pluripotent stem (iPS) cells in Cell and the next year multiple groups along with Yamanaka’s reported creating human iPS cells. It’s no exaggeration

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Where will STAP cell mess go from here & key unanswered questions

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STAP-stem-cells-hope-or-mirage-201x3001

In some ways it’s hard to imagine that it was only just over 6 months ago that Nature published the two STAP cell papers by a collaborative team of Japanese and American researchers. It feels like years have gone by since then because so much has happened related to the STAP mess including the retraction of the

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Where does STAP cell mess go from here & key unanswered questions

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STAP-stem-cells-hope-or-mirage

In some ways it’s hard to imagine that it was only just over 6 months ago that Nature published the two STAP papers by a collaborative team of Japanese and American researchers. It feels like years have gone by since then because so much has happened related to the STAP mess including the retraction of

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Reflecting on Sasai tragedy, STAP, & flawed field of science

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Yoshiki_Sasai_circa_2012

Today has been a dark day of mourning for science following the death by suicide of Dr. Yoshiki Sasai. I did not know Dr. Sasai personally, but was very impressed with his work. His suicide leaves me feeling very sad and it seems like an appropriate time for reflection. (update I did a post on suicides by

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