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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

October 3, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some […]

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Wearing ‘Good Genes’: Trump & Eugenics

October 1, 2017 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Is President Donald Trump a fan of eugenics? He seems to believe that he comes from greatly superior genetic stock. He hasn’t said much of anything about CRISPR ‘gene editing’ technology that can readily alter the genetic code of cells of nearly any organism, including humans, but Trump has a fascination with the concept of

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Customers rate Nervana stem cell clinic harshly on Yelp

September 7, 2017 / Professor Paul Knoepfler, Ph.D. / 11 Comments

Sacramento’s Nervana stem cell clinic has been selling non-FDA approved stem cell therapies to patients for a variety of conditions including arthritis, pain, and neuropathy for a while now since last year, but in my opinion there isn’t good evidence to back up using amniotic or fat stem cells for such conditions. Further, my understanding

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Six questions as FDA takes new shot at stem cell clinics

August 28, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The FDA issued a historic statement today promising to more clearly define its regulatory policies on stem cell therapies and to take strong action on some stem cell clinics that it views as “bad actors”. I’ve never the FDA use such clear-cut language before. I give big kudos to new FDA Commissioner Scott Gottlieb. It already

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Scientist’s dilemma: find a public voice on big issues or stay silent?

August 22, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There is a scientist’s dilemma: should you speak out on important, sometimes controversial issues in science, where you not only can potentially have positive impact, but also risk being attacked for it? Or do you remain silent? I’ve now been blogging for more than 7 years. I’ve battled the often exploitive for-profit stem cell clinics

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Hallelujah it’s raining money? Stem cell job ad is window into clinics & their finances

August 11, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

“Are you a motivational speaker?” is how a recent stem cell job ad for a sales position related to stem cell clinics begins. This ad that popped up on Monster earlier this summer is a revealing window on stem cell clinic practices. What’s inside, in my opinion, is cause for concern. Lately we’ve seen more and more ads for stem

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3 Ways Stem Cells Theoretically May Help John McCain Beat Brain Tumor

July 23, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I was really sad when I heard about John McCain’s diagnosis with a glioblastoma, a particularly nasty type of brain tumor that we study in my lab when it shows up in children. My own battle with prostate cancer starting almost 8 years ago might have sensitized me to this news even though I’m in

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Blunt comment from stem cell industry insider in defense of RTT & Texas Law

July 18, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

My recent post on the push for National Right-To-Try (RTT) including a detailed comment from ISSCR stirred some animated feedback. In the spirit of encouraging diverse discussion, here I am posting a striking comment I received from a stem cell industry insider regarding that post on RTT as it relates to stem cells and s/he was especially

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FIX IT! SF Chronicle runs striking stem cell clinic ad with coupon

June 27, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

I’ve seen stem cell clinic ad after ad pop up in the mainstream media in my own hometown in The Sacramento Bee paper, but others are sprouting as well and a friend sent me a particularly striking stem cell advertisement from a recent copy of the San Francisco Chronicle. Not only does this stem cell clinic

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Highlights of ISSCR2017 – A Biomedical Engineer’s Perspective

June 25, 2017 / Professor Paul Knoepfler, Ph.D.

ISSCR meeting review By Agnes Soos Amid the hustle and bustle of downtown Boston, nearly four thousand researchers and exhibitors gathered for the 15th Annual ISSCR Meeting. With presentations from over thirty plenary lectures, and dozens of others featured in concurrent sessions and the daily Innovation Showcases, there definitely was no shortage of exciting research

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