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David Baltimore, et al. path for human germline engineering

March 19, 2015 / Professor Paul Knoepfler, Ph.D.

In a new perspectives piece in Science, Nobel Laureate David Baltimore and co-authors including Jennifer Doudna and George Church, chart a potential path forward for human germline engineering. See also accompanying Bioethics piece by Gretchen Vogel as well, “Embryo engineering alarm”. In the piece, entitled “A prudent path forward for genomic engineering and germline gene […]

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ISSCR calls for moratorium on clinical application of human germline nuclear genome editing

March 19, 2015 / Professor Paul Knoepfler, Ph.D.

The International Society for Stem Cell Research (ISSCR) just now released a new policy statement on human germline gene editing. The statement calls for a ban on clinical application of human germline gene editing technology. Here is the brief summary statement at the beginning: The International Society for Stem Cell Research calls for a moratorium on

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Weekend Reads from a Wild, Fun Week of Science

March 14, 2015 / Professor Paul Knoepfler, Ph.D.

You might enjoy the recommended reads below and find they surprise and educate you. Products in the pipeline – Ocata’s RPE by Alexey, a nice update on Ocata. Yes, we are seeing more attacks on academic freedom: guest post by historian of science and medicine. Guest piece by Alice Dreger on her new book, Galileo’s Middle Finger.

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Tips for Visiting Stockholm During ISSCR 2015 by Heather Main

March 11, 2015 / Professor Paul Knoepfler, Ph.D.

Stockholm-Sweden-Riddarholmen-ChurchBy-Unknown

Note that you can register for ISSCR Stockholm here and the early registration deadline is today, March 11. Even without ISSCR Stockholm is a city worth visiting! There is no Eiffel Tower, Colosseum or Big Ben but Stockholm is one of Europe’s best kept secrets and the most beautiful European city I have visited. This

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Weekend Reads: Cool Papers, PubPeer, Jacob Hanna, & More

March 7, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Here are some papers and news for weekend reads. What are you reading this weekend? What are your go-to stem cell journals? Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and

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Are babies from same-sex couples possible?

March 3, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

A question that has come up with advances in stem cell technology: could same-sex couples have their own biological children? Since Shinya Yamanaka reprogrammed first mouse and then human ordinary cells into powerful pluripotent stem cells, termed induced pluripotent stem (iPS) cells, back in 2006-2007 many new research avenues have opened up. The impossible suddenly

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ViaCyte CEO Laikind Interview: Trial Update, Melton, & Future

March 2, 2015 / Professor Paul Knoepfler, Ph.D.

VC-01-post-implant-final1-e1503703572933, viacyte

It’s been exciting to watch the recent developments in using stem cells as the basis for treatments for Type I Diabetes. One of the major players in this arena is the privately-held company, ViaCyte. In this post, I interview ViaCyte President and CEO, Paul Laikind. The topics include their VC-01 product, the Encaptra device, an update on

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Monday, March 2: My Reddit AMA on 3-Person IVF, Mitochondrial Transfer

February 27, 2015 / Professor Paul Knoepfler, Ph.D.

On Monday, I’ll be doing another Reddit AMA, this time on 3-person IVF also known as 3-parent IVF, mitochondrial transfer, 3-parent babies, etc. You can see the upcoming AMAs including mine listed in the right sidebar here. Mine will start at 10AM PST/1PM EST. I hope to discuss with a wide audience all the key

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Super Science Weekend Reading

February 21, 2015 / Professor Paul Knoepfler, Ph.D.

Here’s some thought-provoking weekend reading. ALEXEY. CLINICAL CELL PROCESSING NEWS – PART 1, 2015 BIOPOLITICAL TIMES. MITOCHONDRIAL MISSION CREEP AND THE CLONING CONNECTION CALIFORNIA STEM CELL REPORT. CALIFORNIA’S BOB KLEIN PROPOSES $100 BILLION, INTERNATIONAL STEM CELL/GENOMICS VENTURE CARL ZIMMER. A NEW THEORY ON HOW NEANDERTHAL DNA SPREAD IN ASIA DN LEE. YOU SHOULD KNOW: MICHELLE HUNTER AND EXPLORING NEUROSCIENCE THROUGH

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