September 30, 2020

The Niche

Knoepfler lab stem cell blog

Doc grows new nose on top of patient’s head

New NoseWe all have heard the expression “eyes on the back of one’s head”, but a nose on top of one’s head?

What the heck?

A Chinese doctor has apparently grown a new nose on top of a patient’s forehead. The patient had his nose damaged by an injury and then also ravaged by infection.

It makes perfect sense to bioengineer a new nose for the man, but it’s a puzzling story in this case for many reasons.

Why, for example, grow the nose on the man’s forehead instead of right where his nose is?

According to the Associated Press:

Surgeons previously have used cartilage to help rebuild noses in their proper position and are experimenting with growing new ones from stem cells on other parts of the body, such as a forearm. This was the first known case of building a nose on a forehead.

The notion of growing a new nose or ear to replace an injured one is backed by solid science, but why grow it on top of a forehead? This odd approach means the nose has to be moved and that the forehead must be injured to remove the nose.

Also, I wonder, why in this case did the doctor grow the nose with the nostrils up? This seems illogical as the openings could collect dust or water leaving the patient prone to infection.

Apparently the logic for growing the new nose on the head is that the skin on the forehead is similar to nose skin say as compared to the skin of the arm, which would have been more inconspicuous but have less nose-like skin.

There is also promise in engineering new body parts such as noses, ears, and even internal organs from stem cells.

One of the aspects of this news story on growing the nose, highlighted in this LA Times story, that I found most interesting is that the practice of fixing injured noses goes back to ancient times.

The Sushruta Samhita, a Sanskrit text, described the surgical tools, herbs and techniques necessary for nasal reconstructive surgery, and offered this bit of advice to practitioners: “Operation without trembling, fear, or doubt are always praiseworthy of the surgeon operating.”

The text is attributed to Sushruta, a physician who is believed to have lived about 600 BC.

Today, the sky or should I say the human body is the limit when it comes to bioengineering new body parts. I can only imagine where we’ll be in as little as twenty years.
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