The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) to reduce the burden of mutant mitochondrial DNA (mtDNA). Their work was done primarily in mice, but also using chimeras made with murine oocytes fused with human cells bearing …Read More
Rumors have been flying for months that researchers in China and possibly elsewhere were shopping papers around at high-profile journals that reported gene editing and genetic modification of human embryos. Update: apparently this paper (HT to @JohnBorghi) was only reviewed for 2 days (see image at bottom of post), raising major concerns about the depth of peer review. The rumors were right. Today, one of the Chinese teams of researchers published their paper on genetically modified (GM) human embryos in the journal Protein & Cell. …Read More
There is no hotter technology than CRISPR-Cas9 gene editing tools. Perhaps it is not surprising then that there is a patent dispute over it, which falls into two camps: (1) Jennifer Doudna & Emmanuelle Charpentier, and (2) Feng Zhang. Who deserves the intellectual property for use of CRISPR-Cas9 in human cells? Take our poll.
I invited the Chief Scientific Officer (CSO) of Bioheart, Kristin Comella, to do an interview after hearing some buzz that this could be a critical time for the company and that it might have been recently visited by the FDA. Note that Comella not just Bioheart CSO, but also the primary instructor for physician training in stem cell methods offered by the company US Stem Cell Training. Can you update us on how Bioheart is doing with its clinical trials/INDs? Comella: Our completed clinical trials of …Read More
Hockey legend Gordie Howe had a devastating stroke last fall and supposedly a stem cell treatment in Mexico from for-profit stem cell businesses, Stemedica and Novastem, caused a remarkable recovery in Howe. It has been one of the most hyped stem cell stories in history. What really happened? Today a new article on a fresh investigation into this story sheds some important additional light on it including the bombshell that Howe’s family has invested in Stemedica. For background, the Howe treatment was given via stem cell company Stemedica …Read More
Controversial TV physician Dr. Mehmet Oz hasn’t had a great year what with his disastrous testimony before Congress. (2020 Update; Dr. Oz recently had a good show on stem cell clinics so that’s something. I discussed issues with his staff prior to the show.) Now Dr. Oz has been slammed by a group doctors from across the country. Update: Orac points out that these doctors have some of their own baggage when it comes to science. They reportedly want him removed from Columbia because of …Read More