December 1, 2020

The Niche

Knoepfler lab stem cell blog

Month: January 2017

2 min read

In the whirlwind that is the stem cell and regenerative medicine world, there are many concerning things that need attention, but also good stuff happens too and this post focuses on the positive. The Asterias spinal cord injury clinical trial, a phase 1/2a trial called SCiStar, continues to make encouraging news with a clean safety profile and additional hints at possible positive indicators of efficacy. With the usual, important caveats such as that this is early and it is not an RCT, the SCiStar momentum …Read More

3 min read

It was just over a decade ago that I started making websites and it’s been a wild ride. My first site was at the domain name www.chromatin.com, which I was fortunate to have been able to get for a good deal way back when…I think in 2005. You can see here an early 2007 copy of the archive of one of my first versions of the Knoepfler lab website at chromatin.com. I first put up that website around the time that I moved here to …Read More

2 min read

The first ten days of Donald Trump’s presidency have been just as extreme as many had feared including those of us in the scientific community, but the early reactions of scientists to fight Trump’s agenda have been encouraging. We’ve collectively been sparked to “get out of the lab” and do something about it. There are many things one can do as a scientist to oppose Trump’s extremism. I wrote a post on December 2 about how scientists can try to deal with the new Trump …Read More

3 min read

A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes from a team led by Juan Carlos Izpisua Belmonte including first author Jun Wu, and also with important contributions from Pablo Ross’s lab here at UC Davis The big news …Read More