One of my favorite types of papers are those on stem cells and chromatin, and a new one in Current Biology caught my eye this week. My own lab website has the URL chromatin.com so that says something. You can also read more about our research here.
(A) Representative time-lapse images of a neuroblast expressing the DNA marker His2A::RFP and the cortical marker Sqh::GFP.”
Recommended reads: chromatin and stem cells, more
- Asymmetric nuclear division in neural stem cells generates sibling nuclei that differ in size, envelope composition, and chromatin organization, Current Biology
- CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells, Nat Cell Bio. Here’s another new stem cell chromatin paper. CTCF seems to have many roles, but I never get tired of reading about it.
- Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration, Stem Cells Translational Medicine.
- Exploring the human lacrimal gland using organoids and single-cell sequencing, Cell Stem Cell
- Compromised dental cells viability following teeth-whitening exposure, Sci Reports. I know this one is a bit out of left field, but given the tens of millions of people who whiten their teeth, it’s important to know the consequences for cell biology.
FDA sends more untitled letters; bigger action coming?
- CBER targets four stem cell firms with untitled letters, RAPS. CBER is the branch of the FDA that deals with cell therapies including stem cells along with other products. I have to wonder why we are still seeing untitled letters and no more concrete action from the agency. Maybe these are just continuations of actions already underway from spring. Is some big action against dozens or even hundreds of non-compliant clinics coming before year’s end? I hope so. The FDA sure has raised expectations for some far beyond untitled letters or even a few warning letters.