Recommended reads: secrets of cells, T-cells, CRISPR

What are your favorite cells? The stem variety? T-cells? I have a hard time choosing just one favorite.

The first news item I feature talks new imaging methods to see deep inside any cells. Have a favorite organelle?

Cryo-EM of cells — Cryo-Electron Tomography view inside a cell. “Cryo-electron tomography reveals a phase-separated protein degradation microcompartment where proteasomes (red) cluster at the endoplasmic reticulum membrane (cytosolic ribosomes: light blue; membrane-bound ribosomes: dark blue; Cdc48: yellow; membranes: white; Protein structures obtained by subtomogram averaging and subsequently mapped back into the cellular tomogram). Data courtesy of Dr. Benjamin Engel, Helmholtz Zentrum München.”

The secret lives of cells — as never seen before, Nature. This news item covers newer imaging techniques like cryo-ET. You can see one of the images above.

Beam Therapeutics Reports Preclinical Data Highlighting Multiplex Base Editing Approach to Create Anti-CD5 CAR T-cell Investigational Therapies for T-Cell Malignancies. Beam PR.

For stem cells, bigger doesn’t mean better, MIT News. Cell size and the mechanisms that control cell growth (as in getting bigger, not necessarily proliferating) are fascinating. Sometimes smaller is better too.

Pubs on stem cells & more

Human neural tube morphogenesis in vitro by geometric constraints, Nature.
Weighing up the evidence used by direct-to-consumerstem cell businesses, Stem Cell Reports.
Generation of functional ciliated cholangiocytes from human pluripotent stem cells, Nat Comm.
Opening the window for endothelial-to-hematopoietic transition, G&D.
Mesenchymal stromal cell apoptosis is required for their therapeutic function, Nat Comm. MSCs have to spill their guts to help disease?
Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development, G&D.
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing, Nat Comm. For those of us doing CRISPR we need to consider what other mutations may pop up along the way. Especially in a preclinical pipeline.

Recommended reads: secrets of cells, T-cells, CRISPR

Pubs on stem cells & more

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