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FDA chides US doc who genetically modified human embryo in reported 3-person IVF

August 4, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The FDA sent a stern letter today to Dr. John Zhang, PhD, MD, the physician who last year created a genetically modified human embryo in the U.S. and then exported it to Mexico where he self-reported creating a genetically modified baby boy. While the genetically modified baby created in Mexico was reportedly seemingly OK, it’s not clear […]

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First 3-person IVF baby born via “rogue” experiment at Mexico clinic?

September 27, 2016 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Today we got the first report of a baby being born via so-called “3-person IVF”, sometimes called 3-parent IVF, in which the DNA of three people contribute to an offspring. Before discussing this further I have to emphasize that we need proof that this is indeed really a 3-person IVF baby via genetic testing. Until that

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NAS proposes prudent US policy on 3-person IVF

February 3, 2016 / Professor Paul Knoepfler, Ph.D. / 3 Comments

A new report from the National Academies of Sciences (NAS), Engineering, and Medicine here in the US recommends a policy significantly more cautious on first read for 3-person IVF than that in place now in the UK. My initial take on this new 164-page report is that it is very well thought out and the

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Nature mixed signals on 3-person IVF: deep risks, but forge ahead

October 11, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Nature recently published a thorough, insightful piece on the major risks that would come with the use of so-called 3-person IVF (aka mitochondrial transfer or 3-parent baby method). In the UK 3-person IVF has, as of earlier this year, the government’s blessing to proceed despite the many serious unresolved risks that Nature‘s own piece so nicely

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250,000-fold oversight on 3-person IVF mitochondrial transfer?

June 23, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Remember the debate over so-called 3-person IVF? The goal of this technology, also referred to as mitochondrial transfer and 3-parent IVF, is to prevent mitochondrial disease through nuclear transfer in oocytes or one-cell embryos. The resulting genetically modified (GM) human embryos and ultimately children if it works could have dodged mitochondrial disease, but also could have serious or

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Monday, March 2: My Reddit AMA on 3-Person IVF, Mitochondrial Transfer

February 27, 2015 / Professor Paul Knoepfler, Ph.D.

On Monday, I’ll be doing another Reddit AMA, this time on 3-person IVF also known as 3-parent IVF, mitochondrial transfer, 3-parent babies, etc. You can see the upcoming AMAs including mine listed in the right sidebar here. Mine will start at 10AM PST/1PM EST. I hope to discuss with a wide audience all the key

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UK OKs 3-Person IVF: Perspectives

February 25, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

With the House of Lords vote yesterday, the UK officially became the only country in the world to have legalized human genetic modification via 3-Person IVF. The point of this “mitochondrial transfer” or “3-person IVF” technology is not directly to genetically modify humans specifically, but it still will lead to that result in any case.

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Red flags in Sally Davies letter on 3-person IVF mitochondrial transfer

February 24, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

There’s been some back and forth between me and some members of the UK Parliament and others in the UK on the issue of mitochondrial transfer or 3-person IVF technology. Some of this has involved the UK equivalent of the Surgeon General, Professor Dame Sally Davies, who at one point apparently called my views “bunk”. I

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UK Surgeon General Calls My Concerns on 3-person IVF “Bunk”

February 23, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What is one to do when the equivalent of the Surgeon General of the UK calls one’s concerns about something, in this case 3-person IVF, “bunk”? It sure gave me some pause. What’s going on? First, some brief background. The debate over 3-person IVF/mitochondrial transfer technology has been getting more heated. The epicenter for the discussion

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Nature Biased News Coverage of 3-Person IVF

February 13, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

NatureNews is a science news outlet so I’ve been wondering what the heck the deal is with their strongly biased news coverage of the mitochondrial transfer 3-person IVF technology debate. By way of context, I like NatureNews and am a regular reader, but their coverage of the mitochondrial transfer debate has been completely one-sided and inaccurate. Their

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