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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and […]

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Weekly reads: clonal expansion, Golden Retriever cancer, FTC hits genetics firm on testi-phony-als

November 26, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Let’s start this week’s digest with a discussion of clonal expansion and mutations during cell and gene therapy development. Here’s the article that brought this to mind. Sickle cell gene therapy process may cause cancer-linked mutations in blood stem cells, Fierce Biotech. Clonal expansion This is a story about a non-CRISPR gene therapy using a

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Conversation with Harmit Malik on Gene Drive & Genetics

August 16, 2015 / Professor Paul Knoepfler, Ph.D.

Gene drive is a powerful, emerging genetic technology that can force genetic modification into an entire population. For more background on gene drive you can read my previous post. It’s a very exciting, but potentially dangerous technology with sizable possible risks. Recently I had an intriguing conversation with leading geneticist Harmit Malik on gene drive. What

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White House Gets Going on Genetics

July 11, 2015 / Professor Paul Knoepfler, Ph.D.

The White House seems to be getting more active on genetics in the last six months. It’s refreshing to see them actually talking about real, important science. My feeling has been that up until now they’ve been giving too little attention to science so even if you may disagree with some aspects of what they

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New iPS cell conventional wisdom from polls: epigenetics & mutations remain concerns, immunogenicity not so much

May 10, 2013 / Professor Paul Knoepfler, Ph.D. / 1 Comment

I recently did a series of 4 polls on potential roadblock issues in the iPS cell field. The impetus for these polls was my sense that there were substantial differences in views on whether iPS cells were now proven to be equivalent to ES cells in 4 key ways. Turns out the polls got a

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Polls on key iPS cell attributes: epigenetics, memory, mutations, immune issues

May 7, 2013 / Professor Paul Knoepfler, Ph.D.

Just how good are today’s iPS cells? Are they essentially functionally the same as ES cells? Take our polls below to let us know your thoughts.

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A layman’s guide to stem cell epigenetics

September 29, 2011 / Professor Paul Knoepfler, Ph.D.

I know you care about stem cells and research, but do you know much about epigenetics? You should. If you do not understand epigenetics then you do not understand stem cells. Don’t be put off by the complicated sounding name “epigenetics”. It’s really simple conceptually and below is your easy-to-understand guide. Epigenetics controls nearly every

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Stanford’s Mike Snyder and wellness coach Tony Robbins together yield some puzzling research

September 25, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Mike Snyder and Tony Robbins, Stanford Tony Robbins

What do you think of when I mention Stanford professor Mike Snyder and self-help guru Tony Robbins together? I would not necessarily have imagined them forming a connection but science is full of surprises. I’ve admired Snyder’s work in genetics for a long time. I’m most familiar these days with Robbins for his interest in

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