We all know people who seem far younger than their age, which feeds into the idea of biological age. It’s often in the news these days and all over social media. Some people who are fighting high-profile battles with aging are also doing something I call “health flexing.” I also called these folks by another …
Biological age, health flexing, & stabs at rejuvenation Read More »
Most of us have heard of organoids but what about the related model called an “assembloid”, which is a term growing in use including from organoid researcher Sergiu Pasca of Stanford? Before we jump into that, be sure to enter The Niche stem cell image contest for your chance to win $100 or some swag. …
I’ve been more interested in histones and their modifications versus DNA methylation when it comes to epigenetics and chromatin. In part this has just been because I have studied histones so much more. For example, we have been knocking out the two histone variant H3.3 genes, H3f3a and H3f3b, now for a decade. My lab also …
Weekly reads: DNA methylation, H3 K27M in glioma, memory wipe, teeth Read More »
I’ve been thinking more about the steady stream of epigenetic clock research out there. How convincing is the research on such clocks? Do they tightly relate to human biological age? The related notion of turning back such hypothetical clocks to reverse aging is exciting but controversial. It doesn’t help that some are hyping all of …
Is DNA methylation destiny? Diving into new epigenetic clock research Read More »
The biotech Sarepta has had a complicated go of it with the FDA sometimes related to their Duchenne muscular dystrophy (DMD) gene therapy efforts. In late 2016 I wrote about how there was some controversy as the FDA approved the Sarepta drug eteplirsen (Exondys 51) also for DMD, going against an advisory panel that had …
Weekly reads: Sarepta, epigenomics, FDA on eyedrops Read More »
I’m sure many of you remember He Jiankui, the guy who made CRISPR babies. He ended up serving three years in jail in China. He seems to be trying for something of a comeback since his release. Were He Jiankui invitations a mistake? Some prestigious places have even invited him to give talks, which seemed …
Weekly reads: He Jiankui disappoints, ALS, Vor Biopharma Read More »
With the pandemic still here but less severe there are more in-person conference opportunities including stem cell meetings. It seems certain that moving forward though that there will be far more virtual opportunities too. That’s a good thing. You can see last year’s stem cell & regenerative medicine meetings 2022 page too. 2023 stem cell …
Hub of regenerative medicine & stem cell meetings 2023 Read More »
About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly lived 969 years. The so-called Methuselah gene was at first not a …
Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming Read More »
I tend to perhaps over-focus on human CRISPR or gene editing, but other applications including in agriculture are definitely going to be huge. CRISPR in agriculture One that I’ve been following for a long time is the use of CRISPR to prevent cows from growing horns. Why is that a big deal? Just in the …
Weekly reads: CRISPR chicks, HSCs, sequencing Mendel Read More »
Many celebs seem to be into cosmetics called Augustinus Bader cream products that claim to do something related to stem cells. The brand is wildly expensive. What’s this all about? Augustinus Bader is both a person and a line of cosmetic products. The goal of today’s post is to fact-check the claims and products of the Augustinus …
Wrinkles in pitch of celeb fav Augustinus Bader cream Read More »