Search Results for: Jacob Hanna

‘We don’t want to freak people out’: about that Jacob Hanna human embryo model startup

Jacob Hanna Renewal Bio

Stem cell biologist Jacob Hanna has a new startup called Renewal Bio. Its goal is to harvest cells or tissues from human embryo or fetus models for clinical use. I believe that their commercial ambitions have so far outstripped careful thought and discussion in the broader community of researchers. There are major risks here for …

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Weekend Reads: Cool Papers, PubPeer, Jacob Hanna, & More

journals1

Here are some papers and news for weekend reads. What are you reading this weekend? What are your go-to stem cell journals? Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and …

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Silva Comments on MBD3/NuRD Debate with Jacob Hanna

Jose-Silva

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have …

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, …

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100% reprogramming efficiency reports Jacob Hanna

A team at the Weizmann Institute of Science in Israel led by Jacob Hanna reports today near perfect reprogramming efficiency to make induced pluripotent stem cells (iPSCs) by eliminating a single factor called Mbd3 from the cellular equation. On first glance, the Nature article (Rais, et al.) seems to be all about boosting cellular reprogramming efficiency to close …

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Public stem cell skirmish erupts between Hanna & Jaenisch

Jaenisch-Hanna

Professor Rudolf Jaenisch of MIT and his former postdoc/now assistant professor at The Weizmann Jacob Hanna have gotten into a very public, stem cell skirmish over conflicting papers. Hanna raised concerns over a Jaenisch lab paper and things have escalated from there. This mess is playing out before our eyes on PubMed (there was a comment from Hanna …

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Risks rise as ISSCR drops strict 14-day rule on human embryo growth in the lab

mouse embryos grown outside the lab

Something called the 14-day rule on growing human embryos in the lab helped keep a tough question in check for a long time: when is it ethically wrong or just practically unwise to continue growing a human embryo for research? There is no good answer based on science or anything else. ISSCR moves beyond strict …

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When does a human embryo model become the real thing & other tough questions for a new field

human embryo model mukul tewary sm

A human embryo model is a laboratory-produced collection of living cells that has some key things in common with real human embryos. They are made from pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem cells or iPS cells. This research is both exciting and ethically complicated, raising some difficult questions. Embryo …

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Weekly reads: embryo pubs stir things up, organoids crying, & more

organoids tear glands sm

This was an unusual week in that three papers in a sense collided together related to embryo production and growth, raising new research possibilities but also serious ethical questions. New research: what is an embryo & what is not? The first two Nature papers reported generating the most realistic models of human embryos from scratch …

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Recommended weekend science links

snuppy

Here are some recommended weekend science reads and links including stem cells, CRISPR, and clones. Woo-Suk Hwang & his dog clones…all started with Snuppy (pictured): Disgraced Scientist Clones Dogs, And Critics Question His Intent.Now in 2020, I wonder where Hwang is and what is he doing?  I’m going to look into it. Human gene editing …

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