Search Results for: Jacob hanna

‘We don’t want to freak people out’: about that Jacob Hanna human embryo model startup

Jacob Hanna Renewal Bio

Stem cell biologist Jacob Hanna has a new startup called Renewal Bio. Its goal is to harvest cells or tissues from human embryo or fetus models for clinical use. I believe that their commercial ambitions have so far outstripped careful thought and discussion in the broader community of researchers. There are major risks here for […]

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Weekend Reads: Cool Papers, PubPeer, Jacob Hanna, & More

journals1

Here are some papers and news for weekend reads. What are you reading this weekend? What are your go-to stem cell journals? Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and

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Silva Comments on MBD3/NuRD Debate with Jacob Hanna

Jose-Silva

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff,

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100% reprogramming efficiency reports Jacob Hanna

A team at the Weizmann Institute of Science in Israel led by Jacob Hanna reports today near perfect reprogramming efficiency to make induced pluripotent stem cells (iPSCs) by eliminating a single factor called Mbd3 from the cellular equation. On first glance, the Nature article (Rais, et al.) seems to be all about boosting cellular reprogramming efficiency to close

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Public stem cell skirmish erupts between Hanna & Jaenisch

Jaenisch-Hanna

Professor Rudolf Jaenisch of MIT and his former postdoc/now assistant professor at The Weizmann Jacob Hanna have gotten into a very public, stem cell skirmish over conflicting papers. Hanna raised concerns over a Jaenisch lab paper and things have escalated from there. This mess is playing out before our eyes on PubMed (there was a comment from Hanna

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2023 stem cell predictions grades reflect wild year for regenerative medicine

stem cell predictions

Every year I make stem cell and regenerative medicine predictions. Looking at my predictions for 2023, they reflect a wild year but in many ways a good one overall. Below I have graded my 2023 predictions. Overall, my crystal ball gave solid results. Some of the predictions have been condensed to keep things concise, but you

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Weekly reads: MD Stem Cells, embryo models & headaches, cell therapy trial updates

dr. jeffrey weiss, MD Stem Cells

There is still plenty of reason to worry about unproven stem cells being marketed in the U.S. and elsewhere around the world. I’ll start with a new item here in the U.S. on a firm called MD Stem Cells and end with a newly published paper about how things are going in Poland on this

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Weekly reads: stembryos or human embryo models, new Macchiarini sentence

stembryos, embryo models Monash

Researchers have been making stem cell-based embryo models for years now and a few folks have taken to calling these “stembryos.” Other names like gastruloids and blastoids are sometimes used too. “Embryo models” might be the simplest and best name. The embryo model research has advanced relatively quickly from very basic, not very organized structures

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Stem cell research ethics topics: organoid consciousness & embryo models

brain organoids sm

Someday could human brain organoids get to the point of having organized human-like thoughts? Even consciousness? The more time passes, the less likely I think this is. It’s not impossible, but brain organoids have big limitations in that regard. To be clear, I don’t mean brain organoids having some vaguely human brain-like electrical activity. Even monolayers of

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