Search Results for: belmonte

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

Figure-6B

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) …

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease Read More »

Weekly reads & stem cell news: New York axes NYSTEM, fetal tissue rules reversed, pubs & more

stem cell book

It’s been a week with a wide variety of regenerative medicine papers and stem cell news. Here’s my earlier take from a few days ago on the Belmonte-led human-monkey chimeric embryo paper in Cell that broke this week. A few days ago I also put up a new video on our Stem Cell YouTube Channel …

Weekly reads & stem cell news: New York axes NYSTEM, fetal tissue rules reversed, pubs & more Read More »

Monkey human embryo chimera Cell paper: exciting, ethically complex direction

human embryo chimera

A new Cell paper from an international team led by Juan Carlos Izpisua Belmonte pushes human embryo chimera embryo research further than ever before. It is both exciting work and raises many complex bioethics questions at the same time. What is a human embryo chimera? By way of background, chimeric human embryos contain a mixture …

Monkey human embryo chimera Cell paper: exciting, ethically complex direction Read More »

Can Hearts Repair Themselves Via Stem Cells

heart-stem-cells1

Can hearts repair themselves via their own stem cells? Science evolves Sometimes what we scientists all know to be true turns out later on to be wrong and there are clear instances of this in the stem cell field. For example for decades the dogma was that the adult mammalian brain did not have stem cells, but …

Can Hearts Repair Themselves Via Stem Cells Read More »

Highlights #FOGM18 Day 1: Data from Ancient Dirt, Genomics Dilemmas, CAR-T, & CRISPR

FOGM-venue-Scripps-Seaside-Forum

There are many genomics meetings out there these days, but The Future of Genomic Medicine meeting (#FOGM18) at Scripps in La Jolla is one of my favorites. This meeting is uniquely empowering. The people and the talks combine for a one-of-a-kind experience. The venue doesn’t hurt either at the Scripps Seaside Forum. The evening before the meeting …

Highlights #FOGM18 Day 1: Data from Ancient Dirt, Genomics Dilemmas, CAR-T, & CRISPR Read More »

Perspectives on pig human chimera paper

human-pig-chimera

A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes …

Perspectives on pig human chimera paper Read More »

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease Read More »

Recommended stem cell papers for weekend reading

Below I’ve listed some papers that are recommended for weekend reading. Enjoy. You can find more recent recommended reads here. Cool new heterochromatin stem cell aging paper in Science from Izpisua Belmonte Lab. ESC apoptosis pathway. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells, paper from Jing Huang lab in …

Recommended stem cell papers for weekend reading Read More »

4 areas of debate on 1st human embryo genetic modification paper

human-genetic-modification

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion …

4 areas of debate on 1st human embryo genetic modification paper Read More »

The big blind spot on CRISPR for human embryo editing: PGD

blind-spot

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the …

The big blind spot on CRISPR for human embryo editing: PGD Read More »