Search Results for: belmonte

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

February 1, 2021 / By / 6 Comments
Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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Recommended stem cell papers for weekend reading

February 1, 2021 / By

Below I’ve listed some papers that are recommended for weekend reading. Enjoy. You can find more recent recommended reads here. Cool new heterochromatin stem cell aging paper in Science from Izpisua Belmonte Lab. ESC apoptosis pathway. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells, paper from Jing Huang lab in …

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4 areas of debate on 1st human embryo genetic modification paper

February 1, 2021 / By / 5 Comments
human-genetic-modification

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion …

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The big blind spot on CRISPR for human embryo editing: PGD

February 1, 2021 / By / 10 Comments
blind-spot

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the …

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