Search Results for: crispr

Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / By / 5 Comments
CRISPR Therapeutics

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and …

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Weekly reads: new Sergiu Pasca pub, CRISPR chicken, human gene count update, stem cells in China

October 14, 2023 / By / Leave a Comment
Sergiu Pasca, assembloid

Most of us have heard of organoids but what about the related model called an “assembloid”, which is a term growing in use including from organoid researcher Sergiu Pasca of Stanford? Before we jump into that, be sure to enter The Niche stem cell image contest for your chance to win $100 or some swag. …

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Weekly reads: CRISPR sickle cell, Parkinson’s, pig-human chimera concerns

September 9, 2023 / By / Leave a Comment
CRISPR gene editing

CRISPR gene editing has made rapid progress heading from bench to bedside. Perhaps the fastest has been its progress toward clinical use to combat sickle cell disease. We’ll start with a new paper on one major effort here. CRISPR gene editing. This process often involves cutting DNA, which then can be used as an opening to …

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Weekly reads: Vertex stem cells for diabetes update, new CRISPR , immortality

July 9, 2023 / By / 1 Comment
stem cell therapy for diabetes

Where do things stand with the investigative approach of stem cells for diabetes? 33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells, Medscape. Not the best headline given the few number of participants here. If your study has only two subjects and one responds, someone is going to say, “50% of people had a …

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Weekly reads: gene therapy nod, Nature pub ethics, CRISPR LDL

May 20, 2023 / By / Leave a Comment
Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Totipotency literally means all powerful, but it refers in biology to specific cells. These cells can make every type of cell in the body of an organism plus the extraembryonic tissues needed for development. This includes humans. So if you could reprogram human cells like blood or skin cells into totipotent stem cells, you might …

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Weekly reads: UC Davis Medical School diversity, CRISPR, Parkinson’s

March 25, 2023 / By / 2 Comments
UC Davis Medical School

It’s been almost seventeen years that I’ve been a professor here at UC Davis Medical School. It feels like home. I enjoy teaching our first-year medical students each year. Some end up doing research in my lab. Our school recently got a nice write-up over at STAT News by Usha Lee McFarling on the diversity …

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Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked

March 11, 2023 / By / 1 Comment
Victoria Gray, CRISPR meeting

Where do things stand with potential applications of CRISPR and other gene editing technologies in patients? Overall, things are looking very positive. CRISPR human trials This week the third big international human genome editing meeting took place in London. The summit addressed numerous potential clinical applications. It was good to see the agenda included quite …

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Weekly reads: human CRISPR, MRT risks, private IRBs, skincare

March 4, 2023 / By / Leave a Comment
David Liu, human CRISPR

It’s funny how sometimes there are many new articles about one general topic like this week with heritable (and somatic) human CRISPR gene editing and related tech.  There are clear reasons for optimism in the somatic arena given advancing trials. Germline editing remains highly questionable in my view even just technically. Then there are loads …

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Weekly reads: ChatGPT as author, COVID pub concern, CRISPR kit

January 28, 2023 / By / 1 Comment
Sam Altman, OpenAI, Chat GPT

Have you had the chance to play around on ChatGPT, the open AI? It can “talk” to you in text kind of like a person. I have tried it out. It’s quite interesting to type in scientific questions and see what pops out. Often it is high-quality text and solid ideas, but not always. You …

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Weekly reads: CRISPR chicks, HSCs, sequencing Mendel

December 31, 2022 / By / 1 Comment
CRISPR chicks

I tend to perhaps over-focus on human CRISPR or gene editing, but other applications including in agriculture are definitely going to be huge. CRISPR in agriculture One that I’ve been following for a long time is the use of CRISPR to prevent cows from growing horns. Why is that a big deal? Just in the …

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