July 13, 2020

The Niche

Knoepfler lab stem cell blog

Search Results for: gene drive

2 min read

What’s more worrisome, potential disease-carrying mosquitoes or releasing self-perpetuating CRISPR gene drive out into the wide world to combat them? We know how the mosquitoes would answer that question, right? And they are fighting back, in a sense, at least in the context of experiments. Mosquitoes were able to develop resistance to gene drive intended to harm their population in intriguing even if disappointing recent studies as reported in an excellent piece by Ewen Callaway over at Nature. This area of study has big health implications. …Read More

1 min read

After the NY Times published an article on June 8th on the exciting, controversial technology called gene drive that can alter the genome of an entire species, strangely the article’s headline changed at least twice. The article was focused on a National Academy panel studying this technology. The headline gradually evolved to become much more positive in tone. You can see this evolution below in chronological order from top to bottom. The first headline sounded like there wasn’t much support, while by the time the third title for …Read More

4 min read

Gene drive is a powerful, emerging genetic technology that can force genetic modification into an entire population. For more background on gene drive you can read my previous post. It’s a very exciting, but potentially dangerous technology with sizable possible risks. Recently I had an intriguing conversation with leading geneticist Harmit Malik on gene drive. What makes nuclease-driven gene drive so exciting for genetics? HM: It is very attractive because of its power, speed, and simplicity for genetic studies. As you know from your mouse …Read More