Some folks can view data from early, small clinical trials too skeptically or overly enthusiastically, and maybe that’s going on with some preliminary results from Verve Therapeutics. Good news? Bad news? I’m going to start with two articles about the same news that have very different vibes. What do I think? On the whole, I …
Weekly reads: Verve Therapeutics, Casgevy UK OK, GDNF, MYC Read More »
The Bay Area biotech Conception Bio has an intriguing name. What does “conception” mean here? Scientists can make many things from stem cells. For example, lately I’ve written a lot about stem cell-based human embryo models. Another intriguing area is called in vitro gametogenesis or IVG, where Conception Bio is a leader. IVG means making …
Weekly reads: Conception Bio & IVG, MYC, Stanford Prez resigns Read More »
It’s been quite a ride doing this blog on stem cells and other technologies for more than a dozen years. So far it seems like I’ll keep it going. A large part of the reason is because of people needing good information about our field. Those people include scientists and physicians but also many in …
Weekly reads: Google, stem cells & MS, VSELs, ‘hairy’ organoids, MYC Read More »
Another busy week including on the grant writing treadmill or should I say Mobius strip, but I’m always on the lookout for new reading and this week a lot popped up on regeneration. Also, a paper on healing and scarring. I regularly write about stem cell journals. For a long time, it seems like Cell Stem …
Stem cell reads: regeneration, 8C, MYC, CRISPR babies Read More »
Stem cells may have anti-aging properties, but they are unlikely to be a real fountain of youth. Even so, people are obsessed with aging and stem cells regularly are thought of as “the ticket” for fighting aging. I’ll start today’s recommended reads with that topic and then go on to list some interesting papers of …
Weekly reads: Bezos & stem cells for anti-aging, Myc, more Read More »
Here are some recommended stem cell and other reads for the week ranging from COVID developments to prosecutors finally catching up with a stem cell surgeon who had many patients die to a list of interesting pubs. Because Trump now has COVID, I wondered on Friday if he might consider trying unproven stem cells or …
Recommended reads: Yamanaka review, stem cell indictment, COVID, MYC, more Read More »
There’s a new paper out this week in Cell from the Zaret lab that is very exciting. In this manuscript, Facilitators and Impediments of the Pluripotency Reprogramming Factors’ Initial Engagement with the Genome, Zaret’s team explores how Myc and Oct4, Sox2, and Klf4 (OSK) behave at the genomic level during cellular reprogramming. What are the most …
Review of the new Zaret Cell paper on Myc & OSK in cellular reprogramming Read More »
I recently did a post telling you about one of my favorite molecules, Myc, which is important not only in cancer but also in most, if not all stem cells including iPS cells. There’s a lot more to Myc and how it does it’s tricks in embryonic stem cells and iPS cells. It cannot do …
Often when we dig a little into the science of stem cells, people get turned off by all the strange names of molecules and jargon. However, whether you are a scientist, patient, investor, reporter, etc. there are some aspects of stem cell science that are ‘musts’ to know about. For example, you need to know …
Want to understand stem cells? Then you have to know Myc! Read More »
Yamanaka may have found a way to give exogenous Myc the boot from the iPS cell universe. It has always been a frustration in the iPS cell field that Myc, a proto-oncogene, is so important for reprogramming. Yes, you can make iPS cells (especially mouse) without Myc, but it can be orders of magnitude harder, …