Another busy week including on the grant writing treadmill or should I say Mobius strip, but I’m always on the lookout for new reading and this week a lot popped up on regeneration. Also, a paper on healing and scarring.
I regularly write about stem cell journals. For a long time, it seems like Cell Stem Cell has been the top journal. However, there are some other fantastic journals in this space including Stem Cells.
You can see my most recent post on stem cell journals including impact factors and any notes on the editors or paper submission process.
Okay, on to the weekly reads including on regeneration
- How to protect the first ‘CRISPR babies’ prompts ethical debate, news item at Nature. At some point, it seems like the names of the “babies”, who are now toddlers, may come out, a possibility that raises many of its own ethical questions. I wonder about the damage that He Jiankui’s CRISPR experiment may have done to their genomes.
- 8C-like cells capture the human zygotic genome activation program in vitro, Cell Stem Cell. When it comes to pluripotent stem cells or early embryo cells, they often go by funny names like “2C” or “8C”. This just refers to the number of cells in the embryo and the identity of such cells even if they aren’t in an embryo.
- Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors, Nat. Comm. Single-cell studies are definitely one of the hottest areas of all cell research these days.
- Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing, Cell Stem Cell. See Figure 1a from this paper above. While this paper is more focused on mechanisms, the area of wound healing is one of the most promising in the cell therapy space. On the flip side, MSCs can drive unwanted scar formation after administration to patients.
- Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2, G&D.
- EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis, Nat. Cell Bio. This is a great paper that relates to my interests in both MYC and EZH2 so I need to dig more into it when I have some time.
- BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells, G&D.
- The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow, Cell Stem Cell.
- Glutamine-dependent signaling controls pluripotent stem cell fate, Developmental Cell.