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Weekly reads: stem cells for MS, good news x2, extending dog years, Neuralink updates

December 3, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

For about as long as I’ve been writing The Niche, people have been asking about stem cells for MS. There’s a huge need for new therapies. While a chemo-based approach with autologous hematopoietic stem cell transplantation (HSCT) looks to work for certain cases of multiple sclerosis (although not yet approved in the US), other cell […]

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Weekly reads: artificial wombs, mice with rat brains, Neuralink

September 24, 2023 / Professor Paul Knoepfler, Ph.D. / 3 Comments

It feels like we are marching towards a future in which key aspects of human reproduction, including the use of artificial wombs, could be substantially different than for most of history. The FDA is considering allowing a clinical trial for use of artificial wombs in people. Human trials of artificial wombs could start soon. Here’s

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Weekly reads: stem cell cost, trial death, HSCT for MS, Neuralink

May 28, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

So many things have gotten very expensive these days that it got me thinking this past week again about stem cell cost. For this reason, I’ve been running polls asking people what they’ve paid for stem cells and how many therapies they’ve gotten. Before jumping into our weekly reads, check out those running polls on

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Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked

March 12, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Where do things stand with potential applications of CRISPR and other gene editing technologies in patients? Overall, things are looking very positive. CRISPR human trials This week the third big international human genome editing meeting took place in London. The summit addressed numerous potential clinical applications. It was good to see the agenda included quite

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Weekly reads: Marc Tessier-Lavigne probe, Neuralink on the brain, Ras unchained

December 4, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

We’ll start with a story related to possible research misconduct, Stanford’s President Marc Tessier-Lavigne, and Science Magazine. In some ways the news on Science itself could be the bigger long-term story. Marc Tessier-Lavigne pub investigation, Science oops moment Here’s some of the coverage: Stanford investigates potential misconduct in president’s research, Science. Multiple publications of Marc Tessier-Lavigne

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Weekly reads: cool olfactory tuft cells, T-cell therapy, NK cells

February 11, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Olfactory epithelium, Olfactory histology

There’s a fascinating type of olfactory cell. These so-called tuft cells have unusual characteristics, especially for nose cells. I had never heard of them before until reading a new article. The inside of the nose may not seem like a very attractive place but there are cool “nose stem cells” in there. More broadly, there

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20 stem cell & regenerative medicine predictions for 2024

January 3, 2024 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Each year I make predictions for the stem cell and regenerative medicine field for the following year. Today’s prediction post is focused on what to expect in 2024. You can also see my stem cell predictions for 2023 and my grades on how I did. I also have made a video version of these predictions so please

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2023 stem cell predictions grades reflect wild year for regenerative medicine

December 27, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Every year I make stem cell and regenerative medicine predictions. Looking at my predictions for 2023, they reflect a wild year but in many ways a good one overall. Below I have graded my 2023 predictions. Overall, my crystal ball gave solid results. Some of the predictions have been condensed to keep things concise, but you

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2023 stem cell & regenerative medicine predictions

December 28, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Toward the end of each year, I make stem cell & regenerative medicine predictions for the coming year. It’s a fun tradition here on The Niche that goes way back. The stem cell field has changed dramatically as reflected in each year’s predictions. Here’s a list of past predictions with my grades of how they

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