July 13, 2020

The Niche

Knoepfler lab stem cell blog

Search Results for: organoids

3 min read

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting 2D cultures of various respiratory cells in a dish doesn’t necessarily tell you all you need to know about what goes on in the patient. While 3D organoids aren’t …Read More

2 min read

365 days a year, 24 hours a day stem cells are growing in labs around the world, providing a never-ending stream of data and products, with real hope, good news, and lots of surprises. You can see some past examples of good news in the stem cell and regenerative medicine field highlighted on The Niche here. Today’s post brings 2 examples of recent good news and a brain organoid surprise. And one bonus more about space and when you’d run out of air (or not …Read More

3 min read

There’s a new paper in Cell Stem Cell on esophageal organoids that has really caught people’s attention. It is entitled, “3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.” It comes from a team led by Jianwen Que. Update: I didn’t realize when I first did this post that there were 2 related esophageal organoids papers in the same issue of the journal and the second one led by James M. Wells at Cincinnati Children’s has some cool …Read More

2 min read

What are your typical weekend reads? If you are a scientist, they might often include a great deal of science. I always hope I can find time for reading for pleasure too, but about as close as I get to that is the New York Times on Sunday. Here are some recommended science reads for this weekend including approachable media articles on interesting developments. Blood test shows promise for spotting early cancers. In addition to being a cancer researcher, as a cancer survivor myself and …Read More