Search Results for: pediatric glioma

Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

reciprocal-CRISPR-mutant-H3.3

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give …

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Are glioma stem cells a path to better outcomes?

Glioblastoma

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill …

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Allis lab Science paper on histone H3.3 in pediatric brain cancer

Allis-H3.3-paper-165x3001

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …

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What do sperm have to do with brain tumors?

H3.3

Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3 binds to the actual …

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Weekly The Niche reads: lab-grown embryos & thymus, more

es cells embryos matrigel the niche sm

Today’s The Niche recommended weekly reads post includes both primary papers and also a few media pieces. I’m especially interested in the first piece on making more complex embryo-like structures from ES cells. This is a long way from just making embryoid bodies or EBs. At the end of the post I discuss an article …

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Weekend cell biology reads: Mesoblast COVID-19 deal, pubs

bergert cell stem cell 2020 cell mechanics sm

The COVID-19 pandemic is tearing through the country right as we are starting into the holiday season, but the wheels of science including cell biology keep going and we keep reading all the great work. What news or papers caught your eye? Here are some of the things I have on my list of reading. …

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Weekly reads on organoids, COVID, CRISPR, cold chromatin, more

Cold-chromatin

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like today’s post is helpful. I …

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Weekly reads: ‘junk DNA’, COVID chaos, CRISPR CasΦ, & postdoc opps, more

Retroviral-genes-Junk-DNA-NIHsmall

Here are our weekly recommended regenerative medicine and other notable science reads including a few things on COVID. It’s been quite an interesting week. “Junk DNA” is not so junky, role in differentiation NIH scientists showed how ancient retroviral genes, or “junk DNA”, may play a role in helping stem cells decide to become neurons. This …

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Histone H3.3: giving cells epigenetic flexibility

chromosomal bridge in histone H3.3 knockout

A relatively newly recognized, important player in the stem cell field is a molecule called histone H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. Histone H3.3 knockout My lab has just (April 9) published new studies …

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