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Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

July 14, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give […]

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Weekly reads: DNA methylation, H3 K27M in glioma, memory wipe, teeth

August 20, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

I’ve been more interested in histones and their modifications versus DNA methylation when it comes to epigenetics and chromatin. In part this has just been because I have studied histones so much more. For example, we have been knocking out the two histone variant H3.3 genes, H3f3a and H3f3b, now for a decade. My lab also

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Are glioma stem cells a path to better outcomes?

June 25, 2014 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill

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Allis lab Science paper on histone H3.3 in pediatric brain cancer

April 24, 2013 / Professor Paul Knoepfler, Ph.D.

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a

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Weekly reads: cancer stem cells, encouraging findings, Trump & NIH, proteomics

November 10, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Liver cancer stem cells, cancer stem cells

Cancer stem cells are stem cell-like cells in many tumors that are key contributors to the ability of tumors to persist and recur after treatment. For those reasons, they are also thought to be major targets, including of emerging therapies. Data also suggest that some therapies may create new types of cancer stem cells leading

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Weekend reads: WaPo blows it on COVID, paper-mill detector, adult pluripotent stem cells

December 11, 2022 / Professor Paul Knoepfler, Ph.D. / 5 Comments

"Hofstenia miamia, three-banded panther worms. Credit: Mansi Srivastava and Kathleen Mazza-Curll"

Imagine writing or editing an article for the WaPo about risky, unproven medical interventions for COVID that desperate patients might consider. Then you link directly to the websites selling this stuff in your article. What the heck? WaPo links to risky long COVID “treatments” By linking, you not only are driving customers to these firms,

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What is the connection between sperm and brain tumors?

September 21, 2014 / Professor Paul Knoepfler, Ph.D.

Sperm and brain tumors? Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3

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Weekly reads: Rusty Gage & stem cell awards, ASCL1, stem cells for a vulture

October 27, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

There should be more stem cell awards. Why not recognize more scientists and advocates? I used to do a Stem Cell Person of the Year Award. I have thought about bringing it back. What do you think? Scroll through some past posts on the Stem Cell Person of the Year Award. ISSCR gives out stem

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Weekly reads: heterochromatin, H3.3, Mesoblast bump

March 31, 2024 / Professor Paul Knoepfler, Ph.D. / 1 Comment

My lab is focused in part on chromatin states in stem cells and cancer including heterochromatin. In fact, my lab’s website is chromatin.com. Heterochromatin is dense, often inactive chromatin. By H&E staining and electron microscopy, heterochromatin looks dark compared to the rest of the nucleus, largely composed of euchromatin. Toward the end of my postdoc

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Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more

May 22, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

There’s nothing quite like getting a new paper out as a scientist running a research lab so this week we can celebrate our new pediatric brain tumor study. I’ll start the weekly reads with that paper. Of course, getting new grants is amazing too but there’s more of a feel of completion after a paper

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Search Results for: pediatric glioma