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What are senolytics? Drugs, activator, supplements, risks

senolytics, senolytic drugs

As we age a higher proportion of our cells end up in a senescent state, which has sparked interest in senolytic drugs and a broader area called senolytics research. The goal of today’s post is to give you an overview of this important area. How much data are there on efficacy or safety? Is the …

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Weekly reads: stem cell activator, sleep & stem cells, clonal hematopoiesis

stem cells macrophages, stem cell activator

When people find out that I’m a stem cell researcher, a common question is whether there’s something they can take that is a stem cell activator. I’ve written before about whether there are stem cell boosts that one can do to try to be healthier. Sleep, stem cell activator and clonality Mostly when I bring …

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Weekly reads: fibroblasts, cancer stem cells, Parkinson’s

fibroblasts stained

It seems like the field of cell biology has mixed feelings about fibroblasts so I’m going to start off there with the recommended reads. But first, check out our stem cell YouTube channel as we are steadily heading toward 500 subscribers and 30,000 views. Please subscribe. I’ve pasted one of our top videos below, which …

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Recommended reads: senolytics, cow iPS cells, big CIRM royalty

Senolytics Steve Horvath

When we hear the word senile we might think stereotypically of an older person who has cognitive impairment, but some argue that senility can apply to cells too as they age and that such cells can be targeted by drugs called senolytics. Unfortunately, the supplements industry has picked up on this idea to sell iffy …

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Fact-checking Regenexx: reviews, data, & cost

Map of Regenexx stem cell locations. Screenshot of map from company website.

Stem cell clinic firms often come and go rather quickly, but a few like Regenexx have persisted and even become a brand name. I’ve been writing here on The Niche for more than eleven years about stem cell clinics. Regenexx has been around that whole time. Along with its founder Dr. Chris Centeno. Patients have …

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The Niche weekend reads: Editas mess, The Niche updates, papers

The news of the week relates to an interim clinical trial report from gene-editing firm Editas on its CRISPR trial for a form of vision loss. On to that in a minute. What have you been reading the past week? Below, I include our weekly list of recommended reads. However, first I wanted to give …

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Boning up on stem cells for osteoporosis: good idea, little data so far

osteoporosis, stem cells for osteoporosis

It’s great when an idea like stem cells for osteoporosis just makes so much common sense, but it still requires data. A logical hypothesis is not enough. The point of today’s post is to fact-check the idea of using stem cells for such bone loss. A femur to stand on? Unfortunately, the take-home message is …

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Weekly reads: stem cell videos, cystic fibrosis, papers

stem cell videos

As part of our weekly reads I’m including one of my latest videos in our Stem Cell Channel on YouTube below. This particular video fact-checks stem cell face creams, but I’ve got quite a few more including on stem cell supplements, different kinds of stem cells and more. You might guess my view of such …

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