October 27, 2020

The Niche

Knoepfler lab stem cell blog

Search Results for: teratoma

2 min read

Now and then we will revisit some of our most popular posts and/or posts with the most comments. One of the best: The Monster Tumor: What is a teratoma really? You can go to the link above to read the original post and comments but I’ve pasted the post itself below. In stem cell research there is a lot of talk about a very unusual type of tumor called “teratoma” and researchers often do “teratoma assays”.  The name teratoma literally means something like monster …Read More

3 min read

The trouble with the risk of teratoma presents a stem cell paradox. Stem cells possess two traits lacking in other cells: self-renewal and pluripotency. This duo of defining functions is key to the ability of stem cells to be used to treat patients via regenerative medicine. A paradox exists because while self-renewal and pluripotency are both needed for stem cells to be clinically useful, these cellular traits also are crucial factors in determining how likely stem cells are to cause tumors as a side effect. …Read More

6 min read

Drugs that restore the shape of the errant protein behind cystic fibrosis (CF) have, over the past eight years, helped the majority of patients, who have certain mutations. Gene-corrected stem cells might offer a “mutation agnostic” option to CF. CF results from a glitch in a glycoprotein with the unwieldy name “cystic fibrosis transmembrane conductance regulator”, or CFTR. The proteins normally fold into channels that regulate the flow of ions into and out of cells, controlling the balance of water and salts in linings …Read More

Over the years I’ve done a variety of videos that ended up on YouTube. While most of these were stem cell videos, some deal with other important topics such as CRISPR of human embryos. You can see an image from a PBS interview video at left that was particularly memorable (more below). In this post I include links to these videos and short summaries of what went into them. I’m planning to include many more new videos in the future. You may also find …Read More