Search Results for: transdifferentiation

Transdifferentiation makes a major advance: direct reprogramming of fibroblasts to oligodendrocyte progenitors

Back-to-back papers (here and here) in Nature Biotechnology report the transdifferentiation (now often simply referred to as “direct reprogramming”) of plain old fibroblasts into brain cells called oligodendrocyte progenitor cells (OPCs). OPCs are a remarkably useful kind of brain cell that generates myelin, which insulates nerves. OPCs are thought to have great therapeutic potential for …

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Transdifferentiation meets gene therapy to tackle heart disease

The leading cause of death in America and many other countries of the world is cardiovascular disease (CVD) including heart attacks and strokes. In fact, CVD kills and disables more people than most often top killers combined including cancer. The myth that CVD is a “man’s disease” only makes the situation worse as in reality CVD …

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Transdifferentiation does not make iPS cells obsolete

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Do we still need iPS cells if transdifferentiation is so cool? Wait, how did we get to the point that people are asking me that extreme question? When iPS cells were first introduced to the world by Shinya Yamanaka, who I think will win the Nobel Prize sometime in the next few years, some folks went …

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21 Stem Cell Research & Regenerative Medicine 2021 Predictions

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In any given field of biomedical science like stem cell research and regenerative medicine, it’s very useful if you can accurately predict the future. It seems, though, that predictions are far more difficult within the more exciting and rapidly-changing fields. The field of stem cells and regenerative medicine fits that bill. Past stem cell research …

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Call for 31 Anversa retractions by Harvard; heart stem cell concept broken?

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In a stunner, Harvard and Brigham & Women’s Hospital reportedly have jointly called for the retraction of 31 papers on heart stem cell research authored by embattled heart stem cell researcher Piero Anversa. The scoop on this by STAT/Retraction Watch written by Ivan Oransky and Adam Marcus gives further details on this mess and past …

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Stem cell & regenerative medicine news: cool pubs, people, ARM, & more

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How does one keep up with all the regenerative medicine and stem cell happenings? There is always something happening in the stem cell and regenerative medicine field ranging from science to policy matters. This post is an update on some recent stem cell happenings that I see as notable or interesting. New Pubs Direct reprogramming …

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CRISPR to make IPS cells: review of new Ding lab paper

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CRISPR and IPS cells are two of my favorite things so when they come together as in a cool, new paper from Sheng Ding’s lab, I’m excited to read it and curious as to what the scoop is. Since 2006-2007 when mouse and human reprogramming were first reported, many different methods have been explored to …

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10 provocative stem cell questions: what are your answers?

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There’s always debate about stem cells and regenerative medicine, right? There are very strong opinions in our field. Here is a list of 10 current, provocative questions. I have my own ideas about the answers to these. Weigh in with comments with your answers. I’m going to do a follow up post with some discussion of the …

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Big stem cell news: dynamic duo of all-chemical direct reprogramming reports

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There’s some big, positive news on the stem cell front today. Two new innovative papers both by teams led by Sheng Ding of Gladstone Institutes with UCSF report all-chemical direct reprogramming of human somatic cells. Ding’s team took skin cells and by exposing them to cocktails of small molecules was able to turn them directly into …

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Weekend reads: sperm, stem cells, chimeras, STAP, DNA Apps

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Here are some cool science reads to enjoy this weekend. Lab-grown sperm made from stem cells can’t swim, but are able to fertilize eggs, reports Eric Boodman over at STAT. Mouse-human neural crest chimeras: Not only a matter of black and white. Clever title. Antonio Regalado writes about a DNA App Store coming soon to a …

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