Aging

Nature paper claims young CSF fights brain aging in mice

old mice get young CSF

A new Nature paper argues that young CSF fights brain aging. Young CSF vs. young blood CSF is the cerebrospinal fluid that surrounds the brain, including those of young mice. The claim is that when young CSF is injected into the brain/CNS cavity of old mice, it makes the aged brains seem younger. And function …

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Altos Labs: mission, leadership, jobs, & CIRM

Altos Labs

At the beginning of the year I wrote about a new kind of biotech called Altos Labs. It’s very different in some ways from other institutions. I find it an intriguing research entity. Where do things stand now with Altos Labs a few months later? More information, new ideas,  and questions have popped up in the …

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Recommended reads: senolytics, cow iPS cells, big CIRM royalty

Senolytics Steve Horvath

When we hear the word senile we might think stereotypically of an older person who has cognitive impairment, but some argue that senility can apply to cells too as they age and that such cells can be targeted by drugs called senolytics. Unfortunately, the supplements industry has picked up on this idea to sell iffy …

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Weekly reads: aging, CRISPR delivery, hair, oocytes, paralysis

CRISPR-Model-Jacob-Corn-e1464305007640

The big news of the week was the launch of Altos labs and their ambitious plan to tackle aging through cell therapies. Altos has recruited a large number of top cell biologists away from academia. That team plus top biotech execs and a $3B war chest make Altos one to watch in coming years. I …

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Perspectives on Altos Labs and its $3B cellular rejuvenation push

Altos Labs PIs

I wrote briefly a few months ago about Altos Labs. It’s a new kind of biotech institute that is focused on cellular reprogramming. My original piece was sparked in part by an article around the same time by Antonio Regalado over at MIT Tech Review. He provided some tantalizing details on Altos. Also, I had heard some …

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Weekly reads: New FDA guidance, brains, MSCs, senescence

human mouse marmoset brain

This week marked the release of new draft FDA guidance on cell and gene therapies. Is the FDA kind of like the guidance counselor at school or more like the principal? It probably depends on many factors. I also find it funny how pretty much everyone in academia and biotech industry works to be compliant …

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Weekly reads: Bezos & stem cells for anti-aging, Myc, more

young blood, stem cells anti-aging

Stem cells may have anti-aging properties, but they are unlikely to be a real fountain of youth. Even so, people are obsessed with aging and stem cells regularly are thought of as “the ticket” for fighting aging. I’ll start today’s recommended reads with that topic and then go on to list some interesting papers of …

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Head transplant update: fact check & perspectives

sergio canavero perhaps the leading advocate of head transplant technology

Is a head transplant actually going to be an option for extending life or changing what it means to be human? What about brain transplants? Let’s lump head and brain transplants together. Any possibility of this happening in coming decades? How close are we to that reality in 2022? In today’s post I give an …

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Recommended stem cell reads: retractions, aging, COVID, CRISPR soldiers

lu et al nature eye regeneration

This week we have some interesting new reading including both on the stem cell basic and translational fronts as well as on COVID-19 vaccines. COVID-19 vaccine considerations From Derek Lowe at In The Pipeline on COVID-19 vaccine expectations at Science Translational Medicine, Get Ready for False Side Effects. You can read my views on possible …

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