Aging

What are senolytics? Drugs, activator, supplements, risks

senolytics, senolytic drugs

As we age a higher proportion of our cells end up in a senescent state, which has sparked interest in senolytic drugs and a broader area called senolytics research. The goal of today’s post is to give you an overview of this important area. How much data are there on efficacy or safety? Is the …

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Weekly stem cell reads: aging & cells, iPS cell mutations, gut, more

Stem cells aging

Does aging do something to time so it seems like as you get older that time goes by faster? Remember as a little kid when summer seemed to last forever and car rides could be agonizingly long? I’ve heard two theories on this. One is that the brain’s baseline of activity slows down with aging …

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Weekly reads: $1B Saudi anti-aging push, OCT4 necklace, cancer trial wows, coffee brain

Stem-Cells-Aging, anti-aging

I recently wrote about stem cell-related ideas for anti-aging and even cheating death, but there are of course other approaches including drugs like metformin. A new article outlines a massive research funding plan to tackle aging. Let’s start with that. Recommend reads including anti-aging Saudi Arabia plans to spend $1 billion a year discovering treatments to …

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Cheating death via regenerative medicine or stem cells?

Cheating-death

How does one go about cheating death? As I get older, fighting aging seems more relevant. Having battled a potentially fatal cancer also gave me a taste of mortality. In biomedical research, it seems like living longer has become an obsession for some recently. Cheating death with cell therapies or other regenerative approaches? Could stem …

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Nature paper claims young CSF fights brain aging in mice

old mice get young CSF

A new Nature paper argues that young CSF fights brain aging. Young CSF vs. young blood CSF is the cerebrospinal fluid that surrounds the brain, including those of young mice. The claim is that when young CSF is injected into the brain/CNS cavity of old mice, it makes the aged brains seem younger. And function …

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Altos Labs: mission, leadership, jobs, & CIRM

Altos Labs

At the beginning of the year I wrote about a new kind of biotech called Altos Labs. It’s very different in some ways from other institutions. I find it an intriguing research entity. Where do things stand now with Altos Labs a few months later? More information, new ideas,  and questions have popped up in the …

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Recommended reads: senolytics, cow iPS cells, big CIRM royalty

Senolytics Steve Horvath

When we hear the word senile we might think stereotypically of an older person who has cognitive impairment, but some argue that senility can apply to cells too as they age and that such cells can be targeted by drugs called senolytics. Unfortunately, the supplements industry has picked up on this idea to sell iffy …

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Weekly reads: aging, CRISPR delivery, hair, oocytes, paralysis

CRISPR-Model-Jacob-Corn-e1464305007640

The big news of the week was the launch of Altos labs and their ambitious plan to tackle aging through cell therapies. Altos has recruited a large number of top cell biologists away from academia. That team plus top biotech execs and a $3B war chest make Altos one to watch in coming years. I …

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All about Altos Labs & its $3B cellular rejuvenation push

Altos Labs PIs

I wrote briefly a few months ago about Altos Labs. It’s a new kind of biotech institute that is focused on cellular reprogramming. My original piece was sparked in part by an article around the same time by Antonio Regalado over at MIT Tech Review. He provided some tantalizing details on Altos. Also, I had heard some …

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Weekly reads: New FDA guidance, brains, MSCs, senescence

human mouse marmoset brain

This week marked the release of new draft FDA guidance on cell and gene therapies. Is the FDA kind of like the guidance counselor at school or more like the principal? It probably depends on many factors. I also find it funny how pretty much everyone in academia and biotech industry works to be compliant …

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