Anti-aging

There is a vast amount of anti-aging hype out there. Some of this involves stem cell-related approaches. In posts in this category Professor Paul Knoepfler fact-checks the hype, focusing on data.

I found something Elon Musk & I agree on: pushing back on anti-aging bluster

Elon Musk

Would you guess that Elon Musk might be into using biotechnology in a high-profile way to try to live far longer than usual, say to age 150? That would have been my assumption. There are countless things about Elon Musk that I really don’t like. I also don’t see many issues on which we are …

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Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill

brain aging

What happens during brain aging and how can we tell if dementia is coming? Are there particular early hallmarks? There are an increasing number of medical tests for predicting or detecting dementia. Alzheimer’s disease can often be detected early. But what do patients or their doctors do with such information? Until recently there weren’t any …

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Can trying to cheat death paradoxically kill you sooner?

anti-aging, Dorian Gray

Can you paradoxically kill yourself early by trying to cheat Death? For example, die through risky anti-aging approaches? The question came to mind because such longevity efforts have become more extreme. They also get more hype in the media. I’ve been following the anti-aging space mainly because many interventions involve risky stem cell injections. Those …

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Biological age, health flexing, & stabs at rejuvenation

health flexing, biological age

We all know people who seem far younger than their age, which feeds into the idea of biological age. It’s often in the news these days and all over social media. Some people who are fighting high-profile battles with aging are also doing something I call “health flexing.” I also called these folks by another …

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Is DNA methylation destiny? Diving into new epigenetic clock research

I’ve been thinking more about the steady stream of epigenetic clock research out there.  How convincing is the research on such clocks? Do they tightly relate to human biological age?  The related notion of turning back such hypothetical clocks to reverse aging is exciting but controversial. It doesn’t help that some are hyping all of …

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Some surprises from new analysis of Altos Labs papers

Altos Labs

Altos Labs is an intriguing multi-institution experiment in so-called rejuvenation research all rolled into one biotech. This relatively new entity headquartered in California has multiple Nobel laureates in the biomedical field in leadership. Even more importantly it has a large group of great researchers leading its individual research labs. This all leads to high expectations, …

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Review of new David Sinclair paper, supplements & anti-aging glitz

David sinclair, anti-aging

Who is David Sinclair and why is he all over the media related to anti-aging efforts? This post is my effort to fact-check Sinclair’s statements in the context of the broader rejuvenation arena. In the process I also review his most recent paper from my view as a stem cell and cancer biologist interested in …

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Long telomeres link to disease suggests caution on anti-aging push

long telomeres

Are long telomeres better than short ones? What about older folks lengthening their telomeres somewhat or stabilizing the length? Could this counter aging? As with many things, the story is far more complicated than we might hope. For background, telomeres are special structures protecting the ends of chromosomes. I remember as a young student that …

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Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming

methuselah mouse, anti-aging

About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly lived 969 years. The so-called Methuselah gene was at first not a …

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What are senolytics? Drugs, activator, supplements, risks

senolytics, senolytic drugs

As we age a higher proportion of our cells end up in a senescent state, which has sparked interest in senolytic drugs and a broader area called senolytics research. The goal of today’s post is to give you an overview of this important area. How much data are there on efficacy or safety? Is the …

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