October 21, 2020

The Niche

Knoepfler lab stem cell blog

Aging

5 min read

Stem cells for flu? For me, that idea is new. Some months back there was buzz about the stem cell biotech Longeveron related to its report on early trial data on testing infusions of mesenchymal stem cells for frailty in the aged. Frailty that pops up in some aging folks can manifest in a variety of ways and contribute both to reduced quality of life and mortality. This week a PR firm for Longeveron sent out an email suggesting that the company’s investigational stem …Read More

5 min read

Imagine an old man and a teenager sitting side by side, with blood flowing from the kid to the oldster in a stab at anti-aging. Sort of like a one-way fountain of youth via blood flow…Sci-fi? People are kind of trying it in the real world. A self-described ‘clinical trial’ of a sort by a company called Ambrosia essentially lets you buy an infusion of a younger person’s blood in an attempt at anti-aging for $8,000. Interested? Reportedly tech guru Peter Thiel is: “I’m not convinced yet …Read More

5 min read

Is there a stem cell connection between the brain and aging? Could a type of brain stem cell control whole body aging? A recent big Nature article from the lab of Dongcheng Cai argues an emphatic “Yes” to these questions, at least in mice. In the Zhang, et al paper, entitled “Hypothalamic stem cells control ageing speed partly through exosomal miRNAs”, their team reports the claim that a narrow population of hypothalamic stem cells are directly fighting aging of the entire murine body via a …Read More

3 min read

How does one go about cheating death? Who doesn’t want to cheat death? I know I certainly do. Can stem cells help many people in the immediate future to escape death (pictured here in personified form as Death t from Wikipedia)? Recent headlines on new stem cell-related clinical developments would make you think so and they go a step further to indicate that such miracles are just around the corner. We are all susceptible to such hype. When it was early days after my …Read More