September 20, 2020

The Niche

Knoepfler lab stem cell blog

brain

3 min read

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give them and their families real hope. Our paper is entitled, “Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.” What we did in …Read More

4 min read

What’s new in the stem cell, cell therapy, and regenerative medicine world as well as biomedical science more generally including cancer? There’s quite a bit of news as reflected in media pieces and new pubs. Today’s post is focused on pubs that just came out. For last week’s recommended reads see here. Oct4-Sox2 Nucleosome Binding & Impact in mESCs This is one of my favorite papers of 2020 so far, coming to us from Science. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. I knew from …Read More

4 min read

What’s the deal with Michael Schumacher and his Hail Mary stem cell procedure. Usually when we hear about celebrities getting unproven stem cells, it’s the celebrity themselves or their PR machine hyping it in exchange for something like free treatments or even money from those offering the stem cells for sale, but in the past 2 weeks the buzz over the “Formula One legend” driver Michael Schumacher (see a photo of him during his racing days below) getting a stem cell treatment for brain …Read More

2 min read

Every now and then I collect a bunch of recent science good news that I’ve come across. Here are some past ‘good news’ posts. Today’s post includes such a recent collection and some funny stuff too at the end. Enjoy! BTW, science is not necessarily all about stem cells, right? Talk about good news. 1,000th Condor chick born! The hard-won comeback of the California condor More hope on new ways to battle HIV. Simpler HIV treatment and prevention strategies take center stage Humming  brain? …Read More