July 7, 2020

The Niche

Knoepfler lab stem cell blog

cancer stem cells

3 min read

I was really sad when I heard about John McCain’s diagnosis with a glioblastoma, a particularly nasty type of brain tumor that we study in my lab when it shows up in children. My own battle with prostate cancer starting almost 8 years ago might have sensitized me to this news even though I’m in long-term remission. I also started thinking about whether stem cells could somehow help him fight or even beat the tumor. It turns out that others have been including stem cells …Read More

3 min read

A stem cell biotech in the news this week was one that had mostly flown under the radar previously with aim to zap cancer stem cells. Stemcentrx has a focus on killing cancer stem cells as a novel approach to treating cancer. Antonio Regalado had a nice article yesterday on the company. He reports that Stemcentrx has around a half a billion in funding. It is valued in the billions. These are very unusual figures for a stem cell biotech. Stemcentrx is developing novel cancer therapeutics such …Read More

2 min read

Yesterday I wrote about how difficult it is to tell different cell lines apart, including normal stem cells and cancer stem cells, especially since some accumulate accumulate oncogenic mutations that may make them seem more similar. A new paper is coming out that makes this case on a genomic level. Tomorrow’s Cell Stem Cell edition includes a paper by a team of researchers led by Jeanne Loring that has identified relatively small genomic abnormalities in ESC and iPS cells. While both ESC and iPS …Read More

3 min read

Cancer is a class of diseases that are intimately linked to stem cells. In fact, I would go so far as to call some types of cancer cells and stem cells, cousins. This concept, of a tight relationship between stem and cancer cells, is under intense investigation but at the same time it is something that many stem cell scientists would rather not think about. It is simply reality. A wide variety of cancers exhibit gene expression profiles that share modules with highly pluripotent …Read More