November 27, 2020

The Niche

Knoepfler lab stem cell blog

cancer stem cells

2 min read

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill the people who get them within 1-2 years even with treatments and because today’s therapies for these cancers are themselves extremely harsh, patients’ quality of life is often very …Read More

2 min read

Just how tumorigenic are iPS cells?  The field really doesn’t know at this point. However, a steady stream of papers have raised red flag after red flag about genomic and epigenomic alterations/mutations that are linked to cancer. Of course, then there is the fact that all the genetic changes actually used to make reprogrammed cells in the first palce are linked to cancer: not just Myc, but also Nanog, KLF4, Sox2, loss of p53 function, etc. We all first thought that making iPSCs without …Read More

2 min read

Each year brings more evidence that what causes many cancers is a case of biological betrayal on the part of stem cells via cancer stem cells. I have blogged before about the potential for stem cell-based regenerative medicine therapies to aid cancer patients. I have also written before about my own experiences as a cancer patient. As you can imagine, being a cancer and stem cell scientist but also now a cancer patient/survivor makes me especially eager to find ways to attack cancer.  An …Read More

2 min read

Yesterday I wrote about how difficult it is to tell different cell lines apart, including normal stem cells and cancer stem cells, especially since some accumulate accumulate oncogenic mutations that may make them seem more similar. A new paper is coming out that makes this case on a genomic level. Tomorrow’s Cell Stem Cell edition includes a paper by a team of researchers led by Jeanne Loring that has identified relatively small genomic abnormalities in ESC and iPS cells. While both ESC and iPS …Read More