CRISPR

UK Biologist Kathy Niakan Asks to Make GM Human Embryos For Research

Kathy-Niakan

UK biologist Kathy Niakan has asked governmental permission to make GM human embryos using CRISPR. Earlier this year, a research team in China crossed a scientific line for the first time in history by using gene editing technology called CRISPR-Cas9 to make genetically modified (GM) human embryos. Other researchers around the world including now one

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Kelly Hills interview: human genetic modification & bioethics

Kelly-Hills

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part

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CRISPR off-target effects important, but not severe challenge, says poll

CRISPRCas9poll

In a poll on CRISPR, respondents so far have predominantly viewed potential off-target effects as a moderate (28%) to substantial (25%) problem. The poll is still running if you are interested in participating. As to the more polar answers, only 20% and 4% answered “minor” or “a non-issue”, respectively, while 14% thought that off-target effects

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Congress: FDA should consult religious experts on embryo CRISPR

Crystal_Structure_of_Cas9_in_Complex_with_Guide_RNA_and_Target_DNA

The US Congress recently held its first hearing on human germline genetic modification. The meeting included CRISPR-Cas9 pioneer Jennifer Doudna (see video here) on the panel. See image of Cas9 structure from Wikipedia. CRISPR-Cas9 is a powerful, strikingly efficient tool for genetic engineering of cells and whole organisms. Now Republican congressional leaders have included a

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Doudna & Others Testify to Congress on CRISPR, Human Germline Editing

Jennifer-Doudna

The House Subcommittee on Research and Technology on Tuesday held a CRISPR hearing: “The Science and Ethics of Genetically Engineered Human DNA”. At the meeting, CRISPR pioneer Dr. Jennifer Doudna gave testimony along with Dr. Victor Dzau who is the President of the Institute of Medicine (IOM) of the National Academy of Sciences (NAS), Dr.

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CRISPR critters: Cute pics of Cas9 gene edited animals

CRISPR-mouse

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

CRISPR-primates

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way

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