CRISPR

Kelly Hills interview: human genetic modification & bioethics

Kelly-Hills

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part …

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CRISPR off-target effects important, but not severe challenge, says poll

CRISPRCas9poll

In a poll on CRISPR, respondents so far have predominantly viewed potential off-target effects as a moderate (28%) to substantial (25%) problem. The poll is still running if you are interested in participating. As to the more polar answers, only 20% and 4% answered “minor” or “a non-issue”, respectively, while 14% thought that off-target effects …

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Congress: FDA should consult religious experts on embryo CRISPR

Crystal_Structure_of_Cas9_in_Complex_with_Guide_RNA_and_Target_DNA

The US Congress recently held its first hearing on human germline genetic modification. The meeting included CRISPR-Cas9 pioneer Jennifer Doudna (see video here) on the panel. See image of Cas9 structure from Wikipedia. CRISPR-Cas9 is a powerful, strikingly efficient tool for genetic engineering of cells and whole organisms. Now Republican congressional leaders have included a …

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Doudna & Others Testify to Congress on CRISPR, Human Germline Editing

Jennifer-Doudna

The House Subcommittee on Research and Technology on Tuesday held a CRISPR hearing: “The Science and Ethics of Genetically Engineered Human DNA”. At the meeting, CRISPR pioneer Dr. Jennifer Doudna gave testimony along with Dr. Victor Dzau who is the President of the Institute of Medicine (IOM) of the National Academy of Sciences (NAS), Dr. …

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CRISPR critters: Cute pics of Cas9 gene edited animals

CRISPR-mouse

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM …

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

CRISPR-primates

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way …

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Stanford Human Germline Modification Meeting: Medicine, Science, Ethics, & Law

Greely_Hank

Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of …

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Doudna most deserving of CRISPR Cas9 patent, says poll

CRISPR-Patent-Poll

With more than 250 votes cast, Jennifer Doudna is leading by a decisive margin in a poll asking who deserves the patent for use of CRISPR-Cas9 as a tool. Feng Zhang got only just over half the votes of Doudna. Another take home message from this poll is that a sizable minority–almost one in five– said …

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News bites & rumors on human embryo genetic modification

statment_gene_editing-tech

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal …

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