CRISPR Archives - The Niche

Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked

March 12, 2023 March 11, 2023 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Where do things stand with potential applications of CRISPR and other gene editing technologies in patients? Overall, things are looking very positive. CRISPR human trials This week the third big international human genome editing meeting took place in London. The summit addressed numerous potential clinical applications. It was good to see the agenda included quite …

Weekly reads: big CRISPR mtg, Mesoblast good news, Neuralink spiked Read More »

Weekly reads: human CRISPR, MRT risks, private IRBs, skincare

March 5, 2023 March 4, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

It’s funny how sometimes there are many new articles about one general topic like this week with heritable (and somatic) human CRISPR gene editing and related tech. There are clear reasons for optimism in the somatic arena given advancing trials. Germline editing remains highly questionable in my view even just technically. Then there are loads …

Weekly reads: human CRISPR, MRT risks, private IRBs, skincare Read More »

Updates on CRISPR therapy development and clinical trials

November 22, 2022 November 22, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

When I first heard of CRISPR gene editing I was excited for my lab to try it out, but it seemed a long way from the field having even one CRISPR therapy available to treat human disease. In the Knoepfler lab, we study genetic and genomic programming in human development and disease. Gene editing seemed …

Updates on CRISPR therapy development and clinical trials Read More »

Weekly reads: aging, CRISPR delivery, hair, oocytes, paralysis

January 23, 2022 January 22, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

The big news of the week was the launch of Altos labs and their ambitious plan to tackle aging through cell therapies. Altos has recruited a large number of top cell biologists away from academia. That team plus top biotech execs and a $3B war chest make Altos one to watch in coming years. I …

Weekly reads: aging, CRISPR delivery, hair, oocytes, paralysis Read More »

Clade Therapeutics pursues universal cells for cancer therapy

November 4, 2021 October 9, 2022 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Clade Therapeutics has been pursuing the idea of using gene-editing to make universally compatible cells. The potential here is big. What if you could make cloaked stem cells that could be used to produce cellular therapies that could be given to most patients without fear of immune rejection? Clade Therapeutics Boston Business Journal covers the …

Clade Therapeutics pursues universal cells for cancer therapy Read More »

Ukraine clinic seems to backpedal from CRISPR people idea

April 30, 2021 April 30, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

medeus clinic doctors. their recruitment emails had suggest a goal to crispr people for trait enhancement.

I wrote earlier this week about Medeus clinic in Ukraine seemingly trying to recruit genetics researchers to CRISPR people for trait enhancement. Aiming for CRISPR people with trait enhancement? In the recruitment emails they sent out it seemed fairly clear that they were planning to do CRISPR on people somehow via stem cells. They mentioned …

Ukraine clinic seems to backpedal from CRISPR people idea Read More »

Ukraine clinic plans to sell CRISPR enhancements: hair color, skin, & breast size

April 28, 2021 April 30, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

It was a couple of years back that researcher He Jiankui claimed he made three “CRISPR babies.” No one would think about doing any kind of rogue gene-editing again, right? Not even somatic gene edits. After all, as far as we know he’s in jail. We still don’t know the health risks that these three …

Ukraine clinic plans to sell CRISPR enhancements: hair color, skin, & breast size Read More »

CRISPR critters advancing science & agriculture

October 20, 2020 February 1, 2021 / By Mina Kim / Leave a Comment

CRISPR applications in the real world The “breakthrough” gene-editing tool, CRISPR Cas9, has been utilized for various purposes since its popularization and commercialization in the early 2010s. While possible uses of gene editing in humans tend to get the most attention, the application of CRISPR-Cas9 also encompasses the animal world and the analysis of a …

CRISPR critters advancing science & agriculture Read More »

Weekly reads on organoids, COVID, CRISPR, cold chromatin, more

October 11, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like today’s post is helpful. I …

Weekly reads on organoids, COVID, CRISPR, cold chromatin, more Read More »