July 10, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR

6 min read

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a fan of the idea of doing CRISPR on human embryos for reproductive use, although I have been supportive of limited, thoughtful in vitro gene-editing studies on human embryos. The …Read More

2 min read

There’s never enough time to get all of one’s science reading done, but we can try! It helps to have a list of “to-read” articles, whether actual research articles or media pieces. In the old days, I remember my mentors saying they literally had “piles” of journal articles on their coffee tables, bathrooms, bedrooms, etc. that they needed to read. Here are some past recommended reads. What would be the digital piles of science articles to try to dig into this week? Here are …Read More

4 min read

What’s on your weekend reads list including stem cell papers? In addition to hard-core research papers, I find some bigger picture publications to be helpful too. Then there are just fun items. Every so often I do a post about things that I’m hoping to find time to read over the weekend or that I’ve recently read. Today’s post is one of those items and here are some interesting science reads related in particular to stem cells, cancer, and CRISPR. Stem cell research and …Read More

7 min read

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is it really a good time to be pushing CRISPR babies? The original “CRISPR baby guy” He Jiankui was recently sentenced to three years in prison for a variety of actions …Read More