CRISPR

CRISPR critters advancing science & agriculture

CRISPRd-goats-small

CRISPR applications in the real world The “breakthrough” gene-editing tool, CRISPR Cas9, has been utilized for various purposes since its popularization and commercialization in the early 2010s. While possible uses of gene editing in humans tend to get the most attention, the application of CRISPR-Cas9 also encompasses the animal world and the analysis of a […]

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Weekly reads on organoids, COVID, CRISPR, cold chromatin, more

Cold-chromatin

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like today’s post is helpful. I

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New research on CRISPR gene-editing in stem cells, infographic

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As a pivotal advance in the gene-editing field and timeline, CRISPR continues to be utilized for research on stem cells and human diseases. Today, I will explain some of the most notable recent findings in the stem cell-CRISPR field. To start things off, I have also created an infographic that briefly explains what CRISPR-Cas9 is,

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New human genome editing (HHGE) academy report: solid, but key gaps

The-International-Commission-on-the-Clinical-Use-of-Human-Germline-Genome-Editing-HHGE

Something called, “The International Commission on the Clinical Use of Human Germline Genome Editing” has issued a new report on heritable human genome editing (HHGE). The Commission was convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the U.K.’s Royal Society. This post is my initial take on the summary of

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Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

reciprocal-CRISPR-mutant-H3.3

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give

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Weekly recommended science reads: stem cells, CRISPR, cancer & more

CRISPR-for-muscular-dystrophy.-Zhang-et-al.-Science-2020.-Screenshot-of-Fig.-2-featured-image

There’s never enough time to get all of one’s science reading done, but we can try! It helps to have a list of “to-read” articles, whether actual research articles or media pieces. In the old days, I remember my mentors saying they literally had “piles” of journal articles on their coffee tables, bathrooms, bedrooms, etc.

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Heads up on Hui Yang, another potential aspiring CRISPR baby researcher

-Yui-Hang

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is

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Perspectives on CRISPR baby guy He Jiankui (贺建奎) going to jail

Jiankui-He-who-claims-CRISPR-baby-production

Scientist He Jiankui(贺建奎) has been sentenced to 3 years in prison by Chinese authorities. Two collaborators also will go to jail. A piece in Science by Dennis Normile on the sentencing of He Jiankui ID’d the other two: “His collaborators were identified as Zhang Renli, of a medical institution in Guangdong province, and Qin Jinzhou, from a Shenzhen

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B+ on my report card on my 20 stem cell predictions for 2019

stem-cell-crystal-ball-predictions-1

Last year around this time I took my annual plunge to make 20 predictions for the coming year for the stem cell and regenerative medicine field. I even made a crystal ball graphic to highlight the complexity of the stem cell ecosystem into which these predictions were embedded (see image) for 2019. How’d I do?

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